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DOI	10.1039/d1fo03436g
	Hypoglycemic effects of Rhodiola crenulata (HK. f. et. Thoms) H. Ohba in vitro and in vivo and its ingredient identification by UPLC-triple-TOF/MS
	Yue, Huilan; Wang, Luya; Jiang, Sirong; Banma, Cailang; Jia, Wenjing; Tao, Yanduo; Zhao, Xiaohui
通讯作者	Yue, HL ; Zhao, XH (通讯作者)，Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China.
发表日期	2022
ISSN	2042-6496
EISSN	2042-650X
起始页码	1659
结束页码	1667
卷号	13 期号:3
英文摘要	Rhodiola crenulata (HK. f. et. Thoms) H. Ohba (RC), mainly distributed in the highly cold region of China, has long been used as a medicine/healthy food for eliminating fatigue and increasing blood circulation. This study aimed to evaluate the inhibitory effects of the RCRS extract on alpha-amylase and alpha-glucosidase (sucrase and maltase) in vitro and in vivo, and tentatively analyze and identify its chemical ingredients using UPLC-Triple-TOF/MS. The Rhodiola crenulata RCRS extract had strong inhibitory activities against alpha-amylase, sucrase and maltase with an IC50 of 0.031 mg mL(-1), 0.142 mg mL(-1) and 0.214 mg mL(-1), respectively. Furthermore, the RCRS extract could significantly decrease the postprandial blood glucose (PBG) level of normal mice in a starch tolerance test, and reduce the PBG levels of diabetic mice in a starch/maltose/sucrose tolerance test. UHPLC-Triple-TOF-MS/MS analysis indicated that hydroxybenzoic acids, hydroxycinnamic acids, alcohol glycosides, flavonols and their derivatives were the main active ingredients in the RCRS extract. The results demonstrate that the RCRS extract of Rhodiola crenulata could be employed as a healthy food or medicine for controlling postprandial blood glucose levels.
关键词	ALPHA-GLUCOSIDASE INHIBITORS POSTPRANDIAL HYPERGLYCEMIA CONSTITUENTS GLYCOSIDES SYNERGISM ACARBOSE EXTRACT LEAVES ROOTS
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Food Science & Technology
WOS类目	Biochemistry & Molecular Biology ; Food Science & Technology
WOS记录号	WOS:000746911500001
来源期刊	FOOD & FUNCTION
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254183
作者单位	[Yue, Huilan; Wang, Luya; Jiang, Sirong; Banma, Cailang; Jia, Wenjing; Tao, Yanduo; Zhao, Xiaohui] Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China; [Wang, Luya; Jiang, Sirong; Jia, Wenjing] Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yue, Huilan,Wang, Luya,Jiang, Sirong,et al. Hypoglycemic effects of Rhodiola crenulata (HK. f. et. Thoms) H. Ohba in vitro and in vivo and its ingredient identification by UPLC-triple-TOF/MS[J]. 中国科学院西北生态环境资源研究院,2022,13(3).
APA	Yue, Huilan.,Wang, Luya.,Jiang, Sirong.,Banma, Cailang.,Jia, Wenjing.,...&Zhao, Xiaohui.(2022).Hypoglycemic effects of Rhodiola crenulata (HK. f. et. Thoms) H. Ohba in vitro and in vivo and its ingredient identification by UPLC-triple-TOF/MS.FOOD & FUNCTION,13(3).
MLA	Yue, Huilan,et al."Hypoglycemic effects of Rhodiola crenulata (HK. f. et. Thoms) H. Ohba in vitro and in vivo and its ingredient identification by UPLC-triple-TOF/MS".FOOD & FUNCTION 13.3(2022).