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DOI	10.3390/v14020360
	Anti-Influenza Activity of Medicinal Material Extracts from Qinghai-Tibet Plateau
	Kurskaya, Olga; Prokopyeva, Elena; Bi, Hongtao; Sobolev, Ivan; Murashkina, Tatyana; Shestopalov, Alexander; Wei, Lixin; Sharshov, Kirill
通讯作者	Kurskaya, O ; Prokopyeva, E (通讯作者)，Fed Res Ctr Fundamental & Translat Med, Lab Mol Epidemiol & Biodivers Viruses, Novosibirsk 630117, Russia. ; Prokopyeva, E (通讯作者)，Novosibirsk State Univ, Med Dept, Novosibirsk 630090, Russia.
发表日期	2022
EISSN	1999-4915
卷号	14 期号:2
英文摘要	To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (Avena sativa L., Hordeum vulgare Linn. var. nudum Hook. f., Hippophae rhamnoides Linn., Lycium ruthenicum Murr., Nitraria tangutorum Bobr., Nitraria tangutorum Bobr. by-products, Potentilla anserina L., Cladina rangiferina (L.) Nyl., and Armillaria luteo-virens) from the Qinghai-Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 mu g/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom A. luteo-virens. These extracts significantly reduced the infectivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6-125 mu g/mL. Two extracts (N. tangutorum by-products and P. anserina) had no A/H3N2 virus inhibitory activity. Notably, the extract obtained from the fruits of N. tangutorum and N. tangutorum by-products exhibited different anti-influenza effects. The results suggest that extracts of A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens contain substances with antiviral activity, and may be promising sources of new antiviral drugs.
关键词	NATURAL-PRODUCTS DRUG DISCOVERY POLYSACCHARIDES OPTIMIZATION GENOMICS GLUCAN
英文关键词	extract; A; sativa; H; vulgare; rhamnoides; L; ruthenicum; N; tangutorum; C; rangiferina; luteo-virens; antiviral drugs
语种	英语
WOS研究方向	Virology
WOS类目	Virology
WOS记录号	WOS:000762490700001
来源期刊	VIRUSES-BASEL
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254155
作者单位	[Kurskaya, Olga; Prokopyeva, Elena; Sobolev, Ivan; Murashkina, Tatyana; Shestopalov, Alexander; Sharshov, Kirill] Fed Res Ctr Fundamental & Translat Med, Lab Mol Epidemiol & Biodivers Viruses, Novosibirsk 630117, Russia; [Prokopyeva, Elena] Novosibirsk State Univ, Med Dept, Novosibirsk 630090, Russia; [Bi, Hongtao] Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Pharmacol & Safe, Xining 810008, Peoples R China; [Wei, Lixin] Northwest Inst Plateau Biol, CAS Key Lab Tibetan Med Res, Xining 810001, Peoples R China
推荐引用方式 GB/T 7714	Kurskaya, Olga,Prokopyeva, Elena,Bi, Hongtao,et al. Anti-Influenza Activity of Medicinal Material Extracts from Qinghai-Tibet Plateau[J]. 中国科学院西北生态环境资源研究院,2022,14(2).
APA	Kurskaya, Olga.,Prokopyeva, Elena.,Bi, Hongtao.,Sobolev, Ivan.,Murashkina, Tatyana.,...&Sharshov, Kirill.(2022).Anti-Influenza Activity of Medicinal Material Extracts from Qinghai-Tibet Plateau.VIRUSES-BASEL,14(2).
MLA	Kurskaya, Olga,et al."Anti-Influenza Activity of Medicinal Material Extracts from Qinghai-Tibet Plateau".VIRUSES-BASEL 14.2(2022).