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DOI	10.1016/j.ijbiomac.2021.11.010
	Gentiana straminea Maxim. polysaccharide decolored via high-throughput graphene-based column and its anti-inflammatory activity
	Shi, Shuo; Wang, Guocheng; Liu, Jie; Liu, Sunan; Xu, Qiuyu; Lan, Xi; Feng, Jianxing; Sun, Jing; Zhang, Wentao; Wang, Jianlong
通讯作者	Wang, JL (通讯作者)，Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China.
发表日期	2021
ISSN	0141-8130
EISSN	1879-0003
起始页码	1727
结束页码	1733
卷号	193
英文摘要	Gentiana straminea Maxim. exhibits various biological activities. However, the purification and functions of polysaccharides in Gentiana straminea Maxim. have never been reported. Herein, by proposing a flexible 3D graphene-based decoloration column (3DD column), Gentiana straminea Maxim. polysaccharide (GMP) was high-throughput obtained and its anti-inflammatory activity was investigated. Benefiting from the large macroporous network of 3D NH2 -graphene oxide hydrogel with selective adsorption towards pigments, the 3DD column exhibits high decoloration ratio (96.41%). In addition, the 3DD column provides superior practical functionality as compared to the traditional approaches, which are time-consuming and need toxic solvents, and exhibiting widespread-application for the purification of polysaccharide from other common plant species. More importantly, the decolored GMP as a natural product has promising anti-inflammatory activity on RAW264.7 cells without negative impact on cell viability. Overall, this work reveals a new functional polysaccharides and provides a flexible approach for polysaccharide decoloration, exhibiting a promising prospect for natural polysaccharides in practical application of pharmaceutical.
关键词	OXIDE ADSORPTION PERFORMANCE EXTRACT AEROGEL DYE
英文关键词	Gentiana straminea Maxim; Polysaccharides; 3D graphene-based decoloration column; Anti-inflammatory activity
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号	WOS:000734374500001
来源期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254154
作者单位	[Shi, Shuo; Wang, Guocheng; Liu, Jie; Liu, Sunan; Xu, Qiuyu; Lan, Xi; Feng, Jianxing; Zhang, Wentao; Wang, Jianlong] Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China; [Sun, Jing] Chinese Acad Sci, Qinghai Prov Key Lab Qinghai Tibet Plateau Biol R, Northwest Inst Plateau Biol, Xining 810008, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Shi, Shuo,Wang, Guocheng,Liu, Jie,et al. Gentiana straminea Maxim. polysaccharide decolored via high-throughput graphene-based column and its anti-inflammatory activity[J]. 中国科学院西北生态环境资源研究院,2021,193.
APA	Shi, Shuo.,Wang, Guocheng.,Liu, Jie.,Liu, Sunan.,Xu, Qiuyu.,...&Wang, Jianlong.(2021).Gentiana straminea Maxim. polysaccharide decolored via high-throughput graphene-based column and its anti-inflammatory activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,193.
MLA	Shi, Shuo,et al."Gentiana straminea Maxim. polysaccharide decolored via high-throughput graphene-based column and its anti-inflammatory activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 193(2021).