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DOI	10.1016/j.foodchem.2021.129435
	Characterization, antioxidant, and neuroprotective effects of anthocyanins from Nitraria tangutorum Bobr. fruit
	Chen, Shasha; Zhou, Haonan; Zhang, Gong; Dong, Qi; Wang, Zhenhua; Wang, Honglun; Hu, Na
通讯作者	Hu, N (通讯作者)，Northwest Inst Plateau Biol, CAS Key Lab Tibetan Med Res, Xining 810008, Peoples R China.
发表日期	2021
ISSN	0308-8146
EISSN	1873-7072
卷号	353
英文摘要	An anthocyanin-rich extract was obtained from Nitraria tangutorum Bobr. fruit, namely ANF, and its composition, antioxidant and neuroprotective effects were studied. Nine anthocyanins were identified from the ANF using UPLC-Triple-TOF/MS analysis, and cyanidin-3-[2 ''-(6 '''-coumaroyl)-glucosyl]-glucoside (C3G) is the most abundant anthocyanin (87.06%). ANF exhibited high ferric reducing antioxidant power (FRAP) and ABTS radical scavenging activity. The online HPLC-DPPH screening revealed that C3G contributed the highest antioxidant capacity. ANF showed potential neuroprotective effects by relieving D-Galactose-induced memory deficits, reducing overexpression of receptor for advanced glycation end products (RAGE) and amyloid-beta42 (A beta 42) in the hippocampus of rats. Besides, ANF could inhibit oxidative stress by reducing the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) in the hippocampus, while elevating amounts of total superoxide dismutase (T-SOD) and glutathione (GSH) in the serum of rats. Thus, ANF has great potential in the development of food and health products related to antioxidant and neuroprotective effects.
关键词	OXIDATIVE STRESS NEUROINFLAMMATION EXTRACTION
英文关键词	Nitraria tangutorum Bobr; Anthocyanin; Composition; Antioxidant; Neuroprotective effects
语种	英语
WOS研究方向	Chemistry ; Food Science & Technology ; Nutrition & Dietetics
WOS类目	Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
WOS记录号	WOS:000655543300011
来源期刊	FOOD CHEMISTRY
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254133
作者单位	[Chen, Shasha; Zhou, Haonan; Zhang, Gong; Dong, Qi; Wang, Zhenhua; Wang, Honglun; Hu, Na] Northwest Inst Plateau Biol, CAS Key Lab Tibetan Med Res, Xining 810008, Peoples R China; [Wang, Honglun; Hu, Na] Chinese Acad Sci, Northwest Inst Plateau Biol, Huzhou Plateau Biol Resource Ctr Innovat, Huzhou 313000, Peoples R China; [Dong, Qi; Wang, Honglun; Hu, Na] Qinghai Prov Key Lab Tibetan Med Res, Xining 810001, Peoples R China
推荐引用方式 GB/T 7714	Chen, Shasha,Zhou, Haonan,Zhang, Gong,et al. Characterization, antioxidant, and neuroprotective effects of anthocyanins from Nitraria tangutorum Bobr. fruit[J]. 中国科学院西北生态环境资源研究院,2021,353.
APA	Chen, Shasha.,Zhou, Haonan.,Zhang, Gong.,Dong, Qi.,Wang, Zhenhua.,...&Hu, Na.(2021).Characterization, antioxidant, and neuroprotective effects of anthocyanins from Nitraria tangutorum Bobr. fruit.FOOD CHEMISTRY,353.
MLA	Chen, Shasha,et al."Characterization, antioxidant, and neuroprotective effects of anthocyanins from Nitraria tangutorum Bobr. fruit".FOOD CHEMISTRY 353(2021).