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DOI	10.1039/d1fo03412j
	Quantitative analysis of resveratrol derivatives in the seed coats of tree peonies and their hypoglycemic activities in vitro/vivo
	Wang, Weidong; Liu, Zenggen; Kong, Fan; He, Lixia; Fang, Linghao; Shu, Qingyan
通讯作者	Liu, ZG (通讯作者)，Chinese Acad Sci, Qinghai Prov Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810001, Peoples R China. ; Liu, ZG (通讯作者)，Chinese Acad Sci, Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810001, Peoples R China. ; Shu, QY (通讯作者)，Chinese Acad Sci, Key Lab Plant Resources, Inst Bot, Beijing 100093, Peoples R China. ; Shu, QY (通讯作者)，Chinese Acad Sci, Beijing Bot Garden, Inst Bot, Beijing 100093, Peoples R China.
发表日期	2022
ISSN	2042-6496
EISSN	2042-650X
起始页码	846
结束页码	856
卷号	13 期号:2
英文摘要	Tree peonies are well-known horticultural and medicinal plants. The tree peony seeds, as emerging woody oil crops, recently have attracted great attention for their metabolites and bioactivities. In this study, the phytochemicals isolated from tree peony seed coats were systematically investigated. Seven polyphenolics were separated and prepared, mainly belonging to resveratrol derivatives. There was a great variation in the seed coat polyphenolic content among eight Paeonia species, and the contents of the resveratrol trimers and dimers were significantly higher in the seed coats of Paeonia ostii than other species. Based on the HPLC fingerprint characteristics and chemometric analysis, a clear discrimination among Paeonia plants was found, including the composition patterns and contents of the constituents. Moreover, the characteristic phytochemicals (vateriferol and trans-epsilon-viniferin) could significantly reduce the starch-mediated levels of postprandial blood glucose in diabetic/normal mice. In addition, in vitro enzyme tests showed that the two compounds could effectively and competitively inhibit alpha-glucosidase, with the IC50 values of 3.01 and 7.75 mu M, respectively, indicating that vateriferol and trans-epsilon-viniferin could be therapeutic potential agents for hyperglycemia and diabetes mellitus.
关键词	ALPHA-GLUCOSIDASE INHIBITORS POSTPRANDIAL HYPERGLYCEMIA ROOT
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Food Science & Technology
WOS类目	Biochemistry & Molecular Biology ; Food Science & Technology
WOS记录号	WOS:000739563500001
来源期刊	FOOD & FUNCTION
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254092
作者单位	[Wang, Weidong; Liu, Zenggen] Chinese Acad Sci, Qinghai Prov Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810001, Peoples R China; [Wang, Weidong; Liu, Zenggen] Chinese Acad Sci, Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810001, Peoples R China; [Kong, Fan; Shu, Qingyan] Chinese Acad Sci, Key Lab Plant Resources, Inst Bot, Beijing 100093, Peoples R China; [Kong, Fan; Shu, Qingyan] Chinese Acad Sci, Beijing Bot Garden, Inst Bot, Beijing 100093, Peoples R China; [He, Lixia] Forestry Sci Tech Extens Stn Gansu Prov, Lanzhou 730046, Peoples R China; [Fang, Linghao] Ruilaiyin Beijing Biotechnol Co Ltd, Beijing 100094, Peoples R China
推荐引用方式 GB/T 7714	Wang, Weidong,Liu, Zenggen,Kong, Fan,et al. Quantitative analysis of resveratrol derivatives in the seed coats of tree peonies and their hypoglycemic activities in vitro/vivo[J]. 中国科学院西北生态环境资源研究院,2022,13(2).
APA	Wang, Weidong,Liu, Zenggen,Kong, Fan,He, Lixia,Fang, Linghao,&Shu, Qingyan.(2022).Quantitative analysis of resveratrol derivatives in the seed coats of tree peonies and their hypoglycemic activities in vitro/vivo.FOOD & FUNCTION,13(2).
MLA	Wang, Weidong,et al."Quantitative analysis of resveratrol derivatives in the seed coats of tree peonies and their hypoglycemic activities in vitro/vivo".FOOD & FUNCTION 13.2(2022).