气候变化领域集成服务门户(CCPortal): Domestication Shapes the Community Structure and Functional Metagenomic Content of the Yak Fecal Microbiota

CCPortal

DOI	10.3389/fmicb.2021.594075
	Domestication Shapes the Community Structure and Functional Metagenomic Content of the Yak Fecal Microbiota
	Fu, Haibo; Zhang, Liangzhi; Fan, Chao; Liu, Chuanfa; Li, Wenjing; Li, Jiye; Zhao, Xinquan; Jia, Shangang; Zhang, Yanming
通讯作者	Zhao, XQ ; Zhang, YM (通讯作者)，Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining, Peoples R China. ; Zhao, XQ ; Zhang, YM (通讯作者)，Qinghai Prov Key Lab Anim Ecol Genom, Xining, Peoples R China. ; Jia, SG (通讯作者)，China Agr Univ, Coll Grassland Sci & Technol, Beijing, Peoples R China.
发表日期	2021
EISSN	1664-302X
卷号	12
英文摘要	Domestication is a key factor of genetic variation; however, the mechanism by which domestication alters gut microbiota is poorly understood. Here, to explore the variation in the structure, function, rapidly evolved genes (REGs), and enzyme profiles of cellulase and hemicellulose in fecal microbiota, we studied the fecal microbiota in wild, half-blood, and domestic yaks based on 16S rDNA sequencing, shotgun-metagenomic sequencing, and the measurement of short-chain-fatty-acids (SCFAs) concentration. Results indicated that wild and half-blood yaks harbored an increased abundance of the phylum Firmicutes and reduced abundance of the genus Akkermansia, which are both associated with efficient energy harvesting. The gut microbial diversity decreased in domestic yaks. The results of the shotgun-metagenomic sequencing showed that the wild yak harbored an increased abundance of microbial pathways that play crucial roles in digestion and growth of the host, whereas the domestic yak harbored an increased abundance of methane-metabolism-related pathways. Wild yaks had enriched amounts of REGs in energy and carbohydrate metabolism pathways, and possessed a significantly increased abundance of cellulases and endohemicellulases in the glycoside hydrolase family compared to domestic yaks. The concentrations of acetic, propionic, n-butyric, i-butyric, n-valeric, and i-valeric acid were highest in wild yaks. Our study displayed the domestic effect on the phenotype of composition, function in gut microbiota, and SCFAs associated with gut microbiota, which had a closely association with the growth performance of the livestock. These findings may enlighten the researchers to construct more links between economic characteristics and gut microbiota, and develop new commercial strains in livestock based on the biotechnology of gut microbiota.
关键词	MULTIPLE SEQUENCE ALIGNMENT GUT MICROBIOTA FATTY-ACIDS WILD GENETICS PLANT PERSPECTIVES METABOLITES EVOLUTION PLATEAU
英文关键词	Yak; domestication; 16S rDNA; shotgun metagenomic sequencing; fecal microbiota
语种	英语
WOS研究方向	Microbiology
WOS类目	Microbiology
WOS记录号	WOS:000641886100001
来源期刊	FRONTIERS IN MICROBIOLOGY
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254071
作者单位	[Fu, Haibo; Zhang, Liangzhi; Fan, Chao; Liu, Chuanfa; Li, Wenjing; Zhao, Xinquan; Zhang, Yanming] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining, Peoples R China; [Fu, Haibo; Zhang, Liangzhi; Fan, Chao; Liu, Chuanfa; Li, Wenjing; Zhao, Xinquan; Zhang, Yanming] Qinghai Prov Key Lab Anim Ecol Genom, Xining, Peoples R China; [Fu, Haibo; Fan, Chao] Univ Chinese Acad Sci, Beijing, Peoples R China; [Li, Jiye] Datong Yak Breeding Farm Qinghai Prov, Datong, Peoples R China; [Jia, Shangang] China Agr Univ, Coll Grassland Sci & Technol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Fu, Haibo,Zhang, Liangzhi,Fan, Chao,et al. Domestication Shapes the Community Structure and Functional Metagenomic Content of the Yak Fecal Microbiota[J]. 中国科学院西北生态环境资源研究院,2021,12.
APA	Fu, Haibo.,Zhang, Liangzhi.,Fan, Chao.,Liu, Chuanfa.,Li, Wenjing.,...&Zhang, Yanming.(2021).Domestication Shapes the Community Structure and Functional Metagenomic Content of the Yak Fecal Microbiota.FRONTIERS IN MICROBIOLOGY,12.
MLA	Fu, Haibo,et al."Domestication Shapes the Community Structure and Functional Metagenomic Content of the Yak Fecal Microbiota".FRONTIERS IN MICROBIOLOGY 12(2021).