气候变化领域集成服务门户(CCPortal): Cytotoxic Effect of Graphene Oxide Nanoribbons on Escherichia coli

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DOI	10.3390/nano11051339
	Cytotoxic Effect of Graphene Oxide Nanoribbons on Escherichia coli
	Qiang, Shirong; Li, Zhengbin; Zhang, Li; Luo, Dongxia; Geng, Rongyue; Zeng, Xueli; Liang, Jianjun; Li, Ping; Fan, Qiaohui
通讯作者	Luo, DX (通讯作者)，Chinese Acad Sci, Northwest Inst Ecoenvironm & Resources, Lanzhou 730000, Peoples R China. ; Luo, DX (通讯作者)，Lanzhou Univ, Coll Earth & Environm Sci, Lanzhou 730000, Peoples R China.
发表日期	2021
EISSN	2079-4991
卷号	11 期号:5
英文摘要	The biological and environmental toxicity of graphene and graphene derivatives have attracted great research interest due to their increasing applications. However, the cytotoxic mechanism is poorly understood. Here, we investigated the cytotoxic effect of graphene oxide nanoribbons (GORs) on Escherichia coli (E. coli) in an in vitro method. The fabricated GORs formed long ribbons, 200 nm wide. Based on the results of the MTT assay and plate-culture experiments, GORs significantly inhibited the growth and reproduction of E. coli in a concentration-dependent manner. We found that GORs stimulated E. coli to secrete reactive oxygen species, which then oxidized and damaged the bacterial cell membrane. Moreover, interaction between GORs and E. coli cytomembrane resulted in polysaccharide adsorption by GORs and the release of lactic dehydrogenase. Furthermore, GORs effectively depleted the metal ions as nutrients in the culture medium by adsorption. Notably, mechanical cutting by GORs was not obvious, which is quite different from the case of graphene oxide sheets to E. coli.
关键词	CARBON NANOTUBES TOXICITY NANOMATERIALS MALONDIALDEHYDE SUPEROXIDE ZINC
英文关键词	graphene oxide nanoribbons; E; coli; cytotoxic effect; oxidative stress; cytomembrane damage
语种	英语
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号	WOS:000657012200001
来源期刊	NANOMATERIALS
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254060
作者单位	[Qiang, Shirong; Li, Zhengbin; Zhang, Li; Zeng, Xueli] Lanzhou Univ, Sch Basic Med Sci, Inst Physiol, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China; [Luo, Dongxia; Geng, Rongyue; Liang, Jianjun; Li, Ping; Fan, Qiaohui] Chinese Acad Sci, Northwest Inst Ecoenvironm & Resources, Lanzhou 730000, Peoples R China; [Luo, Dongxia] Lanzhou Univ, Coll Earth & Environm Sci, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Qiang, Shirong,Li, Zhengbin,Zhang, Li,et al. Cytotoxic Effect of Graphene Oxide Nanoribbons on Escherichia coli[J]. 中国科学院西北生态环境资源研究院,2021,11(5).
APA	Qiang, Shirong.,Li, Zhengbin.,Zhang, Li.,Luo, Dongxia.,Geng, Rongyue.,...&Fan, Qiaohui.(2021).Cytotoxic Effect of Graphene Oxide Nanoribbons on Escherichia coli.NANOMATERIALS,11(5).
MLA	Qiang, Shirong,et al."Cytotoxic Effect of Graphene Oxide Nanoribbons on Escherichia coli".NANOMATERIALS 11.5(2021).