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DOI	10.1039/d1fo01301g
	New steroid saponins from Dioscorea zingiberensis yam and their medicinal use against I/R via anti-inflammatory effect
	Xue, Zhaowei; Cao, Zhen; Jin, Ming; Zhang, Xinxin; Wang, Xinrui; Dou, Jianwei; Zhu, Yuhong; Ito, Yoichiro; Guo, Zengjun
通讯作者	Zhang, XX (通讯作者)，Xi An Jiao Tong Univ, Inst Targeted Drugs Western China Sci & Tec, Xian, Peoples R China. ; Zhang, XX (通讯作者)，Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining, Qinghai, Peoples R China.
发表日期	2021
ISSN	2042-6496
EISSN	2042-650X
起始页码	8314
结束页码	8325
卷号	12 期号:18
英文摘要	Steroid saponins are the medicinal compounds and nutrition ingredients of medicine food homology (MFH) Dioscorea zingiberensis C. H. Wright (D. zingiberensis) yam. Our phytochemical investigation of the edible rhizomes resulted in 9 new furostanol steroid saponins named dioscins A-I (1-9), together with 11 known steroid saponins. Their chemical structures were elucidated based on spectroscopic and chemical analyses. The new dioscins were evaluated for their anti-inflammatory and beneficial effects against cerebral ischemia reperfusion (I/R) injury on RAW264.7 and PC12 cells in vitro, respectively. Dioscins A, B, and G revealed considerable anti-I/R effect through an anti-inflammatory mechanism based on the decreasing concentration of pro-inflammatory (TNF-alpha and IL-6) and down-regulating the NF-kappa B expression. The present research demonstrated that daily consumption of this yam plant probably prevented the I/R occurrence via the anti-inflammatory property of steroid saponins, and it also enriched the steroid saponin library, providing the possibility to develop MFH-containing steroid saponins into functional foods for maintenance of human health or drugs for the treatment of I/R disease.
关键词	CEREBRAL-ISCHEMIA-REPERFUSION METHYL PROTODIOSCIN DIOSGENIN MECHANISMS CHWRIGHT
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Food Science & Technology
WOS类目	Biochemistry & Molecular Biology ; Food Science & Technology
WOS记录号	WOS:000678486000001
来源期刊	FOOD & FUNCTION
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/253983
作者单位	[Xue, Zhaowei; Cao, Zhen; Jin, Ming; Zhang, Xinxin; Dou, Jianwei; Guo, Zengjun] Xi An Jiao Tong Univ, Inst Targeted Drugs Western China Sci & Tec, Xian, Peoples R China; [Zhang, Xinxin] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining, Qinghai, Peoples R China; [Wang, Xinrui] Xianyang Cent Hosp, Xianyang, Peoples R China; [Ito, Yoichiro] Natl Heart Lung & Blood Inst, Biochem & Biophys Ctr, Lab Bioseparat Technol, Natl Inst Hlth, Bethesda, MD USA
推荐引用方式 GB/T 7714	Xue, Zhaowei,Cao, Zhen,Jin, Ming,et al. New steroid saponins from Dioscorea zingiberensis yam and their medicinal use against I/R via anti-inflammatory effect[J]. 中国科学院西北生态环境资源研究院,2021,12(18).
APA	Xue, Zhaowei.,Cao, Zhen.,Jin, Ming.,Zhang, Xinxin.,Wang, Xinrui.,...&Guo, Zengjun.(2021).New steroid saponins from Dioscorea zingiberensis yam and their medicinal use against I/R via anti-inflammatory effect.FOOD & FUNCTION,12(18).
MLA	Xue, Zhaowei,et al."New steroid saponins from Dioscorea zingiberensis yam and their medicinal use against I/R via anti-inflammatory effect".FOOD & FUNCTION 12.18(2021).