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DOI	10.1039/d1fo03761g
	Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS
	Jia, Wenjing; Bi, Qimao; Jiang, Sirong; Tao, Jihong; Liu, Liying; Yue, Huilan; Zhao, Xiaohui
通讯作者	Yue, HL ; Zhao, XH (通讯作者)，Chinese Acad Sci, Qinghai Prov Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810008, Qinghai, Peoples R China.
发表日期	2022
ISSN	2042-6496
EISSN	2042-650X
起始页码	2456
结束页码	2464
卷号	13 期号:5
英文摘要	Codonopsis pilosula (Franch.) Nannf. (CPN), mainly planted in the northwest region, is a traditional Chinese medicine/good health food for nourishing qi and promoting blood circulation. This study firstly evaluated the inhibitory effects of the CPN extraction (CPNE) on alpha-glucosidase in vitro and in vivo, and tentatively confirmed its chemical ingredients by employing UHPLC-Triple-TOF-MS/MS. The CPNE had strong inhibitory activities against mammalian alpha-glucosidase (sucrase and maltase) and yeast alpha-glycosidase with semi-inhibitory concentrations (IC50) of 0.241 mg mL(-1), 0.326 mg mL(-1) and 1.167 mg mL(-1), respectively. In addition, the CPNE could significantly decrease the postprandial blood glucose (PBG) levels in the sucrose/maltose/starch tolerance assays of diabetic mice. Furthermore, a total of 29 compounds, including 3 alkaloids, 13 phenolic acids, 8 alcohol glycosides and 5 alkynosides, were assigned based on comparison with the standards and references, as well as the analysis of main fragments. These results demonstrated that CPN could be used as an adjuvant therapy or dietary supplements to effectively control the occurrence and development of diabetes.
关键词	POSTPRANDIAL HYPERGLYCEMIA POLYSACCHARIDE
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Food Science & Technology
WOS类目	Biochemistry & Molecular Biology ; Food Science & Technology
WOS记录号	WOS:000754014600001
来源期刊	FOOD & FUNCTION
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/253901
作者单位	[Jia, Wenjing; Bi, Qimao; Jiang, Sirong; Tao, Jihong; Liu, Liying; Yue, Huilan; Zhao, Xiaohui] Chinese Acad Sci, Qinghai Prov Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810008, Qinghai, Peoples R China; [Jia, Wenjing; Bi, Qimao; Jiang, Sirong] Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Jia, Wenjing,Bi, Qimao,Jiang, Sirong,et al. Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS[J]. 中国科学院西北生态环境资源研究院,2022,13(5).
APA	Jia, Wenjing.,Bi, Qimao.,Jiang, Sirong.,Tao, Jihong.,Liu, Liying.,...&Zhao, Xiaohui.(2022).Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS.FOOD & FUNCTION,13(5).
MLA	Jia, Wenjing,et al."Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS".FOOD & FUNCTION 13.5(2022).