气候变化领域集成服务门户(CCPortal): Exploring the mechanisms of action of Cordyceps sinensis for the treatment of depression using network pharmacology and molecular docking

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DOI	10.21037/atm-22-762
	Exploring the mechanisms of action of Cordyceps sinensis for the treatment of depression using network pharmacology and molecular docking
	Zhang, Xingfang; Wang, Mengyuan; Qiao, Yajun; Shan, Zhongshu; Yang, Mengmeng; Li, Guoqiang; Xiao, Yuancan; Wei, Lixin; Bi, Hongtao; Gao, Tingting
通讯作者	Gao, TT (通讯作者)，Southern Med Univ, Peoples Hosp Jiangmen, Dept Psychiat, 19 Penglai Rd, Jiangmen 529000, Peoples R China. ; Bi, HT (通讯作者)，Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Pharmacol & Safe, Xining 810008, Peoples R China. ; Wei, LX (通讯作者)，Northwest Inst Plateau Biol, CAS Key Lab Tibetan Med Res, Xining 810001, Peoples R China.
发表日期	2020
ISSN	2305-5839
EISSN	2305-5847
英文摘要	Background: Depression is the most common type of psychological disorder, with continuous, prolonged, and persistent bad moods as the main clinical feature. Cordyceps sinensis is a complex consisting of the ascospores and bodies of insect larvae from the Hepialidae family that have been parasitized by Cordyceps sinensis militaris. Previous studies have reported that this herb has antidepressant activity. The present study used network pharmacology and molecular docking techniques to investigate the potential antidepressant mechanisms of Cordyceps sinensis. Methods: The active ingredients of Cordyceps sinensis were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and the potential targets were predicted using the PharmMapper platform. The GeneCards database was then used to obtain sub-targets for depression. Common targets were screened and enrichment analyses were performed using the Metascape platform. Finally, the relationship between the active ingredients and the core targets were verified by molecular docking. Results: Through network pharmacological analysis, 7 active ingredients in Cordyceps sinensis and 41 common targets of drugs and diseases were identified. The active ingredients of Cordyceps sinensis may exert antidepressant effects by acting on important targets such as catalase (CAT), CREB binding protein (CREBBP), epidermal growth factor (EGF), and E1A binding protein P300 (EP300), and by modulating the signaling pathways in which these targets are involved. Subsequently, the core targets were docked to the active ingredients and good binding was observed. Conclusions: The active ingredients of Cordyceps sinensis may exert antidepressant effects by regulating the CREB binding protein and anti-oxidative stress effects. The foxo signaling pathway (hsa04068), hypoxia-inducible factor 1 (HIF-1) signaling pathway (hsa04066), and Huntington's disease (hsa05016) may be involved in the underlying mechanisms of Cordyceps sinensis. The joint application of network pharmacology
关键词	DRUG TARGET IDENTIFICATION OXIDATIVE STRESS WEB SERVER PATHWAY NEUROGENESIS NEUROBIOLOGY ENVIRONMENT VARIANTS SYMPTOMS UPDATE
语种	英语
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS类目	Oncology ; Medicine, Research & Experimental
WOS记录号	WOS:000772432100001
来源期刊	ANNALS OF TRANSLATIONAL MEDICINE
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/253735
作者单位	[Zhang, Xingfang; Gao, Tingting] Southern Med Univ, Peoples Hosp Jiangmen, Dept Psychiat, 19 Penglai Rd, Jiangmen 529000, Peoples R China; [Zhang, Xingfang; Qiao, Yajun; Yang, Mengmeng; Li, Guoqiang; Xiao, Yuancan; Bi, Hongtao] Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Pharmacol & Safe, Xining 810008, Peoples R China; [Zhang, Xingfang; Wang, Mengyuan; Yang, Mengmeng] Qinghai Univ, Med Coll, Xining, Peoples R China; [Shan, Zhongshu] Peoples Hosp Qinghai Prov, Dept Orthoped Surg, Xining, Peoples R China; [Li, Guoqiang; Xiao, Yuancan; Wei, Lixin] Northwest Inst Plateau Biol, CAS Key Lab Tibetan Med Res, Xining 810001, Peoples R China; [Gao, Tingting] Southern Med Univ, Sch Publ Hlth, Dept Psychol, Guangzhou, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xingfang,Wang, Mengyuan,Qiao, Yajun,et al. Exploring the mechanisms of action of Cordyceps sinensis for the treatment of depression using network pharmacology and molecular docking[J]. 中国科学院西北生态环境资源研究院,2020.
APA	Zhang, Xingfang.,Wang, Mengyuan.,Qiao, Yajun.,Shan, Zhongshu.,Yang, Mengmeng.,...&Gao, Tingting.(2020).Exploring the mechanisms of action of Cordyceps sinensis for the treatment of depression using network pharmacology and molecular docking.ANNALS OF TRANSLATIONAL MEDICINE.
MLA	Zhang, Xingfang,et al."Exploring the mechanisms of action of Cordyceps sinensis for the treatment of depression using network pharmacology and molecular docking".ANNALS OF TRANSLATIONAL MEDICINE (2020).