气候变化领域集成服务门户(CCPortal): Identification of phenolic compounds in fruits of Ribes stenocarpum Maxim. By UHPLC-QTOF/MS and their hypoglycemic effects in vitro and in vivo

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DOI	10.1016/j.foodchem.2020.128568
	Identification of phenolic compounds in fruits of Ribes stenocarpum Maxim. By UHPLC-QTOF/MS and their hypoglycemic effects in vitro and in vivo
	Jiang, Sirong; Zhao, Xiaohui; Liu, Chuang; Dong, Qi; Mei, Lijuan; Chen, Chen; Shao, Yun; Tao, Yanduo; Yue, Huilan
通讯作者	Zhao, XH ; Chen, C ; Yue, HL (通讯作者)，Chinese Acad Sci, Qinghai Prov Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810008, Qinghai, Peoples R China.
发表日期	2021
ISSN	0308-8146
EISSN	1873-7072
卷号	344
英文摘要	The gooseberry (Ribes stenocarpum Maxim. (CBZ)) is a wild and noncommercially cultivated berry fruit widely distributed in the Tibetan Plateau. The phenolic constituents from the berry fruit of CBZ were firstly identified by employing UPLC-QTOF MS. A total of 41 compounds, including hydroxycinnamic acids, hydroxybenzoic acids, flavonols and dihydmflavonol, were identified in view of their molecular weight, characteristic fragment ions and retention times. Further in vitro enzyme assay indicated that CBZ fruit extract could strongly and effectively inhibited alpha-glucosidase and alpha-amylase, with the IC50 values of 0.013 mg/mL and 0.005 mg/mL, respectively. In addition, the starch/maltose/sucrose tolerance experiment demonstrated that the CBZ fruit extract could reduce the sucrose mediated postprandial blood glucose (PBG) levels in normal mice, and significantly lower starch/ maltose/ sucrose mediated PBG levels in diabetic mice. These results suggested that this berry fruit could be used as a dietary supplement, or drug for the control of hyperglycemia.
关键词	POSTPRANDIAL HYPERGLYCEMIA ALPHA-GLUCOSIDASE ACID-DERIVATIVES ANTHOCYANINS INHIBIT AMYLASE L.
英文关键词	Ribes stenocarpum Maxim. phenolic compounds; Postprandial blood glucose; alpha-Glucosidase; alpha-Amylase
语种	英语
WOS研究方向	Chemistry ; Food Science & Technology ; Nutrition & Dietetics
WOS类目	Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
WOS记录号	WOS:000608400000002
来源期刊	FOOD CHEMISTRY
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/253726
作者单位	[Jiang, Sirong; Zhao, Xiaohui; Liu, Chuang; Dong, Qi; Mei, Lijuan; Chen, Chen; Shao, Yun; Tao, Yanduo; Yue, Huilan] Chinese Acad Sci, Qinghai Prov Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810008, Qinghai, Peoples R China; [Jiang, Sirong; Zhao, Xiaohui; Liu, Chuang; Dong, Qi; Mei, Lijuan; Chen, Chen; Shao, Yun; Tao, Yanduo; Yue, Huilan] Chinese Acad Sci, Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810008, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Sirong,Zhao, Xiaohui,Liu, Chuang,et al. Identification of phenolic compounds in fruits of Ribes stenocarpum Maxim. By UHPLC-QTOF/MS and their hypoglycemic effects in vitro and in vivo[J]. 中国科学院西北生态环境资源研究院,2021,344.
APA	Jiang, Sirong.,Zhao, Xiaohui.,Liu, Chuang.,Dong, Qi.,Mei, Lijuan.,...&Yue, Huilan.(2021).Identification of phenolic compounds in fruits of Ribes stenocarpum Maxim. By UHPLC-QTOF/MS and their hypoglycemic effects in vitro and in vivo.FOOD CHEMISTRY,344.
MLA	Jiang, Sirong,et al."Identification of phenolic compounds in fruits of Ribes stenocarpum Maxim. By UHPLC-QTOF/MS and their hypoglycemic effects in vitro and in vivo".FOOD CHEMISTRY 344(2021).