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DOI	10.1016/j.jep.2021.114166
	Genus Ribes Linn. (Grossulariaceae): A comprehensive review of traditional uses, phytochemistry, pharmacology and clinical applications
	Sun, Qing; Wang, Na; Xu, Wenhua; Zhou, Huakun
通讯作者	Xu, WH (通讯作者)，Chinese Acad Sci, Northwest Inst Plateau Biol, 23 Xinning Lu, Xining 810008, Qinghai, Peoples R China.
发表日期	2021
ISSN	0378-8741
EISSN	1872-7573
卷号	276
英文摘要	Ethnopharmacological relevance: The genus Ribes Linn., which belongs to the Grossulariaceae family, contains 160 species distributed mainly in temperate and cold regions of the Northern Hemisphere. There are 59 species in southwest, northwest and northeast China. Some species of Ribes have been used as traditional and local medicines for the treatment of glaucoma, cardiovascular disease, stomachache, hepatitis, hyperlipidemia, hypertension and other ailments. However, the data provided in recent years have not been collated and compared. Aim of the study: This review aims to summarize the current status of ethnopharmacological uses, phytochemistry, pharmacology, clinical applications, and pharmacokinetics of the genus Ribes to better understand the therapeutic potential of the genus Ribes in the future and hope to provide a relatively novel perspective for further clinical application on the genus. Materials and methods: The literature on Ribes was collected through a series of scientific search engines including Elsevier, ACS, Springer, Web of Science, PubMed, Google Scholar, Baidu Scholar, Wiley, China National Knowledge Infrastructure (CNKI) and books. Results: Ribes species have been used for detoxification, glaucoma, cardiovascular disease, stomachache, hepatitis, hyperlipidemia, hypertension and other ailments. These plants mainly contain phenolic glycosides, flavonoids, proanthocyanidins, polysaccharides, etc. Most traditional uses are related to biological activity and have been confirmed by modern research. Pharmacological studies in vitro and in vivo revealed that the extracts and pure compounds possessed significant hypolipidemic, antioxidant, anti-inflammatory, antitumor, antibacterial, and antiviral activity, eyesight protection and other effects. Conclusions: The traditional uses, phytochemistry, pharmacology, pharmacokinetics, and clinical applications described in this article explained that the Ribes species has numerous activities, and these findings will promote further action in the area of mechanism research. However, very few preclinical and clinical studies have focused on the toxicology and pharmacokinetics of crude extracts and pure compounds from the genus Ribes. Moreover, several clinical evidence to support the health benefits of Ribes plants. The development of new medicines based on Ribes species as ingredients may be restricted. The pharmacological activity, clinical efficacy and safety of Ribes species need to be verified by systematic and comprehensive preclinical studies and clinical trials.
关键词	BLACK-CURRANT EXTRACT PERFORMANCE LIQUID-CHROMATOGRAPHY GLUCAGON-LIKE PEPTIDE-1 NIGRUM L. JUICE CHILEAN CURRANTS OXIDATIVE STRESS ESSENTIAL OIL ANTIMICROBIAL ACTIVITY ANTIOXIDANT ACTIVITY PHENOLIC-COMPOUNDS
英文关键词	Ribes species; Grossulariaceae; Traditional uses; Phytochemistry; Pharmacology; Clinical application
语种	英语
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS记录号	WOS:000660251100004
来源期刊	JOURNAL OF ETHNOPHARMACOLOGY
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/253692
作者单位	[Sun, Qing; Wang, Na; Xu, Wenhua; Zhou, Huakun] Chinese Acad Sci, Northwest Inst Plateau Biol, 23 Xinning Lu, Xining 810008, Qinghai, Peoples R China; [Sun, Qing; Wang, Na] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Zhou, Huakun] Key Lab Restorat Ecol Cold Area Qinghai Prov, Xining 810008, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Sun, Qing,Wang, Na,Xu, Wenhua,et al. Genus Ribes Linn. (Grossulariaceae): A comprehensive review of traditional uses, phytochemistry, pharmacology and clinical applications[J]. 中国科学院西北生态环境资源研究院,2021,276.
APA	Sun, Qing,Wang, Na,Xu, Wenhua,&Zhou, Huakun.(2021).Genus Ribes Linn. (Grossulariaceae): A comprehensive review of traditional uses, phytochemistry, pharmacology and clinical applications.JOURNAL OF ETHNOPHARMACOLOGY,276.
MLA	Sun, Qing,et al."Genus Ribes Linn. (Grossulariaceae): A comprehensive review of traditional uses, phytochemistry, pharmacology and clinical applications".JOURNAL OF ETHNOPHARMACOLOGY 276(2021).