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DOI | 10.1016/j.ijbiomac.2021.06.181 |
Nitraria tangutorum Bobr.-derived polysaccharides protect against LPS-induced lung injury | |
Meng, Jing; Deng, Kai; Hu, Na; Wang, Honglun | |
通讯作者 | Wang, HL (通讯作者),Chinese Acad Sci, Northwest Inst Plateau Biol, CAS Key Lab Tibetan Med Res, Xining 810008, Peoples R China. |
发表日期 | 2021 |
ISSN | 0141-8130 |
EISSN | 1879-0003 |
起始页码 | 71 |
结束页码 | 78 |
卷号 | 186 |
英文摘要 | Nitraria tangutorum Bobr. is suggested to be active in immunoregulation and antioxidation. However, the in vivo bioactivity of N. tangutorum Bobr.-derived polysaccharides (NTP) and their anti-inflammatory activity have not been addressed. In the present study, we extracted and purified polysaccharides from N. tangutorum Bobr. and determined their anti-inflammatory activities in vivo. HPGPC, UHPLC/DAD, and NMR analyses identified that the monosaccharide components of NTP were Man, Rha, GalUA, Glu, Gal, and Ara, with relative contents of 3.52%, 15.08%, 10.00%, 26.73%, 38.08%, and 6.59%, respectively. In mice with lipopolysaccharide (LPS)-induced Acute Lung Injury (ALI), NTP treatment attenuated tissue damage, inhibited the production of inflammatory cytokines, and promoted the anti-oxidative response. The supposed mechanism may be via suppressing the Toll -like receptor 4 (TLR4) signaling pathway. In conclusion, our study suggests a protective role of NTP in LPS-induced ALI by inhibiting inflammatory damage. |
关键词 | NF-KAPPA-BSTRUCTURAL-CHARACTERIZATIONANTIOXIDANTFRUITLIPOPOLYSACCHARIDEOPTIMIZATION |
英文关键词 | Acute lung injury; Anti-inflammation; Nitraria tangutorum Bobr; -derived poly-saccharides |
语种 | 英语 |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science |
WOS记录号 | WOS:000688432800008 |
来源期刊 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES |
来源机构 | 中国科学院西北生态环境资源研究院 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/253639 |
作者单位 | [Meng, Jing; Deng, Kai; Hu, Na; Wang, Honglun] Chinese Acad Sci, Northwest Inst Plateau Biol, CAS Key Lab Tibetan Med Res, Xining 810008, Peoples R China; [Hu, Na; Wang, Honglun] Chinese Acad Sci, Huzhou Plateau Biol Resource Ctr Innovat, Northwest Inst Plateau Biol, Huzhou 313000, Peoples R China; [Meng, Jing; Deng, Kai] Qinghai Prov Key Lab Tibetan Med Res, Xining 810001, Peoples R China; [Meng, Jing; Deng, Kai] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Meng, Jing,Deng, Kai,Hu, Na,et al. Nitraria tangutorum Bobr.-derived polysaccharides protect against LPS-induced lung injury[J]. 中国科学院西北生态环境资源研究院,2021,186. |
APA | Meng, Jing,Deng, Kai,Hu, Na,&Wang, Honglun.(2021).Nitraria tangutorum Bobr.-derived polysaccharides protect against LPS-induced lung injury.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,186. |
MLA | Meng, Jing,et al."Nitraria tangutorum Bobr.-derived polysaccharides protect against LPS-induced lung injury".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 186(2021). |
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