气候变化领域集成服务门户(CCPortal): Identification of Somatostatin Receptor Subtype 1 (SSTR1) Gene Polymorphism and Their Association with Growth Traits in Hulun Buir Sheep

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DOI	10.3390/genes13010077
	Identification of Somatostatin Receptor Subtype 1 (SSTR1) Gene Polymorphism and Their Association with Growth Traits in Hulun Buir Sheep
	Li, Xue; Ding, Ning; Zhang, Zhichao; Tian, Dehong; Han, Buying; Liu, Sijia; Liu, Dehui; Tian, Fei; Zhao, Kai
通讯作者	Zhao, K (通讯作者)，Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China. ; Zhao, K (通讯作者)，Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Anim Ecol Gen, Xining 810008, Peoples R China.
发表日期	2022
EISSN	2073-4425
卷号	13 期号:1
英文摘要	This study was conducted to evaluate SSTR1 gene polymorphisms and their association with growth traits in Hulun Buir sheep. We followed 233 Hulun Buir sheep from birth to 16 months of age, born in the same pasture and on the same year under a consistent grazing conditions. The body weight (BW), body height (BH), body length (BL), chest circumference (ChC), chest depth (ChD), chest width (ChW), hip width (HW), and cannon circumference (CaC) were measured and recorded at birth, 4 months, 9 months, and 16 months of age. The polymorphisms of the SSTR1 gene in Hulun Buir sheep were excavated using exon sequencing, and association analyses of between SNPs and growth traits at each growth stage were conducted. The results showed that there were four SNPs in Exon 2 of the SSTR1 gene, SNP1, SNP2, and SNP3 were low mutation sites, and SNP4 was a moderate mutation site. Four SNPs were consistent with Hardy-Weinberg equilibrium, and all of them were synonymous mutations. The association analyses found that the genotypes of SNP2 were significantly associated with WW and BH at 4 months of age, BW, BL, ChC, and HW at 9 months of age (p < 0.05), and extremely significantly associated with ChD at 4 and 9 months of age (p < 0.01). There were significant associations between SNP3 and BH at 9 months of age, between SNP4 and ChD, ChW, and CaC at 9 months of age, and BW and ChC at 16 months of age (p < 0.05). There were no detectable associations with growth traits among the seven haplotypes between the SNP1, 3, and 4 of a strong linkage disequilibrium (p > 0.05). These results indicated that SNP2, SNP3, and SNP4 may be used as molecular markers for growth traits of Hulun Buir sheep.
关键词	SOMATOSTATIN-RECEPTOR GASTRIN-RELEASE ACID-SECRETION EXPRESSION LOCALIZATION
英文关键词	SSTR1; association; growth traits; Hulun Buir sheep
语种	英语
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000759105500001
来源期刊	GENES
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/253613
作者单位	[Li, Xue; Ding, Ning; Zhang, Zhichao; Tian, Dehong; Han, Buying; Liu, Sijia; Liu, Dehui; Tian, Fei; Zhao, Kai] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China; [Li, Xue; Ding, Ning; Zhang, Zhichao; Han, Buying; Liu, Dehui] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Li, Xue; Ding, Ning; Zhang, Zhichao; Tian, Dehong; Han, Buying; Liu, Sijia; Liu, Dehui; Tian, Fei; Zhao, Kai] Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Anim Ecol Gen, Xining 810008, Peoples R China
推荐引用方式 GB/T 7714	Li, Xue,Ding, Ning,Zhang, Zhichao,et al. Identification of Somatostatin Receptor Subtype 1 (SSTR1) Gene Polymorphism and Their Association with Growth Traits in Hulun Buir Sheep[J]. 中国科学院西北生态环境资源研究院,2022,13(1).
APA	Li, Xue.,Ding, Ning.,Zhang, Zhichao.,Tian, Dehong.,Han, Buying.,...&Zhao, Kai.(2022).Identification of Somatostatin Receptor Subtype 1 (SSTR1) Gene Polymorphism and Their Association with Growth Traits in Hulun Buir Sheep.GENES,13(1).
MLA	Li, Xue,et al."Identification of Somatostatin Receptor Subtype 1 (SSTR1) Gene Polymorphism and Their Association with Growth Traits in Hulun Buir Sheep".GENES 13.1(2022).