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DOI	10.1038/s41467-021-22604-3
	The Chinese mitten crab genome provides insights into adaptive plasticity and developmental regulation
	Cui Z.; Liu Y.; Yuan J.; Zhang X.; Ventura T.; Ma K.Y.; Sun S.; Song C.; Zhan D.; Yang Y.; Liu H.; Fan G.; Cai Q.; Du J.; Qin J.; Shi C.; Hao S.; Fitzgibbon Q.P.; Smith G.G.; Xiang J.; Chan T.-Y.; Hui M.; Bao C.; Li F.; Chu K.H.
发表日期	2021
卷号	12 期号:1
英文摘要	The infraorder Brachyura (true or short-tailed crabs) represents a successful group of marine invertebrates yet with limited genomic resources. Here we report a chromosome-anchored reference genome and transcriptomes of the Chinese mitten crab Eriocheir sinensis, a catadromous crab and invasive species with wide environmental tolerance, strong osmoregulatory capacity and high fertility. We show the expansion of specific gene families in the crab, including F-ATPase, which enhances our knowledge on the adaptive plasticity of this successful invasive species. Our analysis of spatio-temporal transcriptomes and the genome of E. sinensis and other decapods shows that brachyurization development is associated with down-regulation of Hox genes at the megalopa stage when tail shortening occurs. A better understanding of the molecular mechanism regulating sexual development is achieved by integrated analysis of multiple omics. These genomic resources significantly expand the gene repertoire of Brachyura, and provide insights into the biology of this group, and Crustacea in general. © 2021, The Author(s).
语种	英语
scopus关键词	ABC transporter; abd a protein; abd b protein; adenosine triphosphatase; adenosine triphosphate; antennapedia protein; cadn protein; chaperone; col protein; cyclic AMP; cyclic AMP dependent protein kinase; cyclic GMP; dfd protein; exd protein; fha5 protein; fha6 protein; fha7 protein; ftz protein; G protein coupled receptor; genomic DNA; gsb protein; heat shock protein; heat shock protein 70; homeobox protein Meis1; hox3 protein; iag protein; idmy protein; insulin; insulin like receptor 1; insulin like receptor 2; kcnn2 protein; kcnn3 protein; lab protein; manganese superoxide dismutase; microRNA; microRNA 10; microRNA 993; microRNA iab 4; microRNA iab 8; n methyl dextro aspartic acid receptor 2B; neurotransmitter; P type ATPase; pb protein; pou6f2 protein; protein tyrosine kinase; relaxin; scr protein; thioredoxin; transcription factor; transcription factor MSX; transcription factor Otx2; transcription factor PAX3; transcription factor Pitx; transcription factor Twist; transcriptome; ubx protein; unclassified drug; zfh1 protein; adaptive radiation; chromosome; crab; developmental biology; gene; genome; genomics; invertebrate; marine ecosystem; osmoregulation; phenotypic plasticity; animal experiment; Article; autosome; confocal laser scanning microscopy; controlled study; developmental stage; down regulation; environmental factor; Eriocheir sinensis; fertility; genome analysis; heterozygosity; Hox gene; invasive species; megalopa; molecular biology; multigene family; nonhuman; osmoregulation; phenotypic plasticity; regulatory mechanism; sexual development; signal transduction; tail; adaptation; animal; aquaculture; Brachyura; chromosomal mapping; female; gene expression profiling; gene expression regulation; genetics; genome; genomics; homeobox; introduced species; life cycle stage; male; physiology; spatiotemporal analysis; whole genome sequencing; Brachyura; Crustacea; Eriocheir sinensis; Invertebrata; Adaptation, Physiological; Animals; Aquaculture; Brachyura; Chromosome Mapping; Female; Fertility; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes, Homeobox; Genome; Genomics; Introduced Species; Life Cycle Stages; Male; Multigene Family; Osmoregulation; Sexual Development; Spatio-Temporal Analysis; Whole Genome Sequencing
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251554
作者单位	School of Marine Sciences, Ningbo University, Ningbo, China; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, China; School of Science and Engineering, University of the Sunshine Coast, Sippy Downs, QLD, Australia; Simon F. S. Li Marine Science Laboratory, School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong; BGI-Qingdao, BGI-Shenzhen, Qingdao, China; 1GENE, Hangzhou, China; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, China; Institute for Marine and Antarctic Studies, University of Tasmania, Hobart, TAS, Australia; Institute of Marine Biology and Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung, Taiwan
推荐引用方式 GB/T 7714	Cui Z.,Liu Y.,Yuan J.,et al. The Chinese mitten crab genome provides insights into adaptive plasticity and developmental regulation[J],2021,12(1).
APA	Cui Z..,Liu Y..,Yuan J..,Zhang X..,Ventura T..,...&Chu K.H..(2021).The Chinese mitten crab genome provides insights into adaptive plasticity and developmental regulation.Nature Communications,12(1).
MLA	Cui Z.,et al."The Chinese mitten crab genome provides insights into adaptive plasticity and developmental regulation".Nature Communications 12.1(2021).