气候变化领域集成服务门户(CCPortal): Genomic insights into the conservation status of the world’s last remaining Sumatran rhinoceros populations

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DOI	10.1038/s41467-021-22386-8
	Genomic insights into the conservation status of the world’s last remaining Sumatran rhinoceros populations
	von Seth J.; Dussex N.; Díez-del-Molino D.; van der Valk T.; Kutschera V.E.; Kierczak M.; Steiner C.C.; Liu S.; Gilbert M.T.P.; Sinding M.-H.S.; Prost S.; Guschanski K.; Nathan S.K.S.S.; Brace S.; Chan Y.L.; Wheat C.W.; Skoglund P.; Ryder O.A.; Goossens B.; Götherström A.; Dalén L.
发表日期	2021
卷号	12 期号:1
英文摘要	Small populations are often exposed to high inbreeding and mutational load that can increase the risk of extinction. The Sumatran rhinoceros was widespread in Southeast Asia, but is now restricted to small and isolated populations on Sumatra and Borneo, and most likely extinct on the Malay Peninsula. Here, we analyse 5 historical and 16 modern genomes from these populations to investigate the genomic consequences of the recent decline, such as increased inbreeding and mutational load. We find that the Malay Peninsula population experienced increased inbreeding shortly before extirpation, which possibly was accompanied by purging. The populations on Sumatra and Borneo instead show low inbreeding, but high mutational load. The currently small population sizes may thus in the near future lead to inbreeding depression. Moreover, we find little evidence for differences in local adaptation among populations, suggesting that future inbreeding depression could potentially be mitigated by assisted gene flow among populations. © 2021, The Author(s).
语种	英语
scopus关键词	conservation status; extinction risk; gene flow; inbreeding depression; local adaptation; mammal; mutation; population decline; population size; animal experiment; Article; Borneo; conservation genetics; demography; Dicerorhinus sumatrensis; gene ontology; genetic conservation; genetic distance; genetic parameters; genetic variability; genome; genomics; heterozygosity; homozygosity; inbreeding; inbreeding depression; local adaptation; mutational load; nonhuman; Perissodactyla; phylogenetic tree; population size; population structure; principal component analysis; X chromosome; animal; endangered species; environmental protection; female; gene flow; genetic selection; genetic variation; genetics; history; Indonesia; loss of function mutation; male; mutation; Perissodactyla; population density; Borneo; Greater Sunda Islands; Sumatra; Sunda Isles; Dicerorhinus sumatrensis; Animals; Borneo; Conservation of Natural Resources; Endangered Species; Female; Gene Flow; Genetic Variation; Genome; History, 21st Century; History, Ancient; Inbreeding; Indonesia; Loss of Function Mutation; Male; Mutation; Perissodactyla; Population Density; Selection, Genetic
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251553
作者单位	Centre for Palaeogenetics, Stockholm, Sweden; Department of Bioinformatics and Genetics, Swedish Museum of Natural History, Stockholm, Sweden; Department of Zoology, Stockholm University, Stockholm, Sweden; Department of Ecology and Genetics, Animal Ecology, Uppsala University, Uppsala, Sweden; Department of Biochemistry and Biophysics, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Stockholm University, Solna, Sweden; Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden; San Diego Zoo Wildlife Alliance, Beckman Center for Conservation Research, Escondido, CA, United States; The GLOBE Institute, University of Copenhagen, Copenhagen, Denmark; Norwegian University of Science and Technology, University Museum, Trondheim, Norway; Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland; LOEWE-Centre for Translational Biodiversity Genomics, Senckenberg, Frankfurt, Germ...
推荐引用方式 GB/T 7714	von Seth J.,Dussex N.,Díez-del-Molino D.,等. Genomic insights into the conservation status of the world’s last remaining Sumatran rhinoceros populations[J],2021,12(1).
APA	von Seth J..,Dussex N..,Díez-del-Molino D..,van der Valk T..,Kutschera V.E..,...&Dalén L..(2021).Genomic insights into the conservation status of the world’s last remaining Sumatran rhinoceros populations.Nature Communications,12(1).
MLA	von Seth J.,et al."Genomic insights into the conservation status of the world’s last remaining Sumatran rhinoceros populations".Nature Communications 12.1(2021).