气候变化领域集成服务门户(CCPortal): A Sarcina bacterium linked to lethal disease in sanctuary chimpanzees in Sierra Leone

CCPortal

DOI	10.1038/s41467-021-21012-x
	A Sarcina bacterium linked to lethal disease in sanctuary chimpanzees in Sierra Leone
	Owens L.A.; Colitti B.; Hirji I.; Pizarro A.; Jaffe J.E.; Moittié S.; Bishop-Lilly K.A.; Estrella L.A.; Voegtly L.J.; Kuhn J.H.; Suen G.; Deblois C.L.; Dunn C.D.; Juan-Sallés C.; Goldberg T.L.
发表日期	2021
ISSN	2041-1723
卷号	12 期号:1
英文摘要	Human and animal infections with bacteria of the genus Sarcina (family Clostridiaceae) are associated with gastric dilation and emphysematous gastritis. However, the potential roles of sarcinae as commensals or pathogens remain unclear. Here, we investigate a lethal disease of unknown etiology that affects sanctuary chimpanzees (Pan troglodytes verus) in Sierra Leone. The disease, which we have named “epizootic neurologic and gastroenteric syndrome” (ENGS), is characterized by neurologic and gastrointestinal signs and results in death of the animals, even after medical treatment. Using a case-control study design, we show that ENGS is strongly associated with Sarcina infection. The microorganism is distinct from Sarcina ventriculi and other known members of its genus, based on bacterial morphology and growth characteristics. Whole-genome sequencing confirms this distinction and reveals the presence of genetic features that may account for the unusual virulence of the bacterium. Therefore, we propose that this organism be considered the representative of a new species, named “Candidatus Sarcina troglodytae”. Our results suggest that a heretofore unrecognized complex of related sarcinae likely exists, some of which may be highly virulent. However, the potential role of “Ca. S. troglodytae” in the etiology of ENGS, alone or in combination with other factors, remains a topic for future research. © 2021, The Author(s).
语种	英语
scopus关键词	ABC transporter; agar; calcium; carbapenem derivative; complementary DNA; DNA 16S; DNA 18S; genomic DNA; lincosamide; ribonuclease; salA protein; unclassified drug; urease; ureE protein; ureF protein; ureG protein; bacterial DNA; bacterium; dilation; disease incidence; medicine; microorganism; morphology; primate; virulence; animal experiment; animal model; animal tissue; Article; bacterial growth; bacterial infection; bacterial virulence; Candidatus sarcina troglodytae; controlled study; disease association; epizootic neurologic and gastroenteric syndrome; epizootiology; female; fisherman; gastrointestinal disease; gel DNA recovery kit; genetic analysis; genus; histopathology; lethality; male; metagenomics; neurologic disease; nonhuman; Pan troglodytes; parasite identification; Sarcina; Sarcina infection; Sarcina ventriculi; Sierra Leone; sudden death; whole genome sequencing; animal; ape disease; classification; emphysema; gastritis; genetics; Gram positive infection; human; microbiology; pathogenicity; procedures; Sarcina; veterinary medicine; virulence; Sierra Leone; Bacteria (microorganisms); Clostridiaceae; Pan troglodytes verus; Sarcina; Sarcina ventriculi; Animals; Ape Diseases; DNA, Bacterial; Emphysema; Gastritis; Gram-Positive Bacterial Infections; Humans; Pan troglodytes; Sarcina; Sierra Leone; Virulence; Whole Genome Sequencing
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251522
作者单位	Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States; Department of Veterinary Science, University of Torino, Torino, Italy; Tacugama Chimpanzee Sanctuary, Freetown, Sierra Leone; Tai Chimpanzee Project, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany; Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany; School of Veterinary Medicine and Sciences, University of Nottingham Sutton Bonington Campus, Sutton Bonington, Leicestershire, United Kingdom; Twycross Zoo, Atherstone, United Kingdom; Genomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, MD, United States; Leidos, Reston, VA, United States; Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD, United States; Department of Ba...
推荐引用方式 GB/T 7714	Owens L.A.,Colitti B.,Hirji I.,et al. A Sarcina bacterium linked to lethal disease in sanctuary chimpanzees in Sierra Leone[J],2021,12(1).
APA	Owens L.A..,Colitti B..,Hirji I..,Pizarro A..,Jaffe J.E..,...&Goldberg T.L..(2021).A Sarcina bacterium linked to lethal disease in sanctuary chimpanzees in Sierra Leone.Nature Communications,12(1).
MLA	Owens L.A.,et al."A Sarcina bacterium linked to lethal disease in sanctuary chimpanzees in Sierra Leone".Nature Communications 12.1(2021).