气候变化领域集成服务门户(CCPortal): Etiological, epidemiological, and clinical features of acute diarrhea in China

CCPortal

DOI	10.1038/s41467-021-22551-z
	Etiological, epidemiological, and clinical features of acute diarrhea in China
	Wang L.-P.; Zhou S.-X.; Wang X.; Lu Q.-B.; Shi L.-S.; Ren X.; Zhang H.-Y.; Wang Y.-F.; Lin S.-H.; Zhang C.-H.; Geng M.-J.; Zhang X.-A.; Li J.; Zhao S.-W.; Yi Z.-G.; Chen X.; Yang Z.-S.; Meng L.; Wang X.-H.; Liu Y.-L.; Cui A.-L.; Lai S.-J.; Liu M.-Y.; Zhu Y.-L.; Xu W.-B.; Chen Y.; Wu J.-G.; Yuan Z.-H.; Li M.-F.; Huang L.-Y.; Li Z.-J.; Liu W.; Fang L.-Q.; Jing H.-Q.; Hay S.I.; Gao G.F.; Yang W.-Z.; Yang W.-Z.; Gao G.F.; Li Z.-J.; Wang L.-P.; Ren X.; Wang Y.-F.; Lin S.-H.; Zhang C.-H.; Geng M.-J.; Wang X.; Jing H.-Q.; Xu W.-B.; Cui A.-L.; Shen Y.-J.; Jiang Y.-Y.; Sun Q.; Hao L.-P.; Ye C.-C.; Liu W.; Zhang X.-A.; Huang L.-Y.; Wang Y.; Zhang W.-Y.; Liu Y.-L.; Wu J.-G.; Zhang Q.; Liu W.-Y.; Sun Z.-Y.; Zhan F.-X.; Xiong Y.; Meng L.; Yu D.-S.; Wang C.-X.; Zhao S.-C.; Wang W.-R.; Lei X.; Li J.-S.; Wang Y.-H.; Zhang Y.; Yang J.-P.; Wang Y.-B.; Quan F.-C.; Xiong Z.-J.; Liang L.-P.; Chang Q.-E.; Wang Y.; Wang P.; Yang Z.-S.; Mao L.-L.; Li J.-M.; Lv L.-K.; Xu J.; Shu C.; Chen X.; Chen Y.; Zhang Y.-J.; Cui L.-B.; Zheng K.-C.; Zhang X.-G.; Zhang X.; Tu L.-H.; Yi Z.-G.; Wang W.; Zhao S.-W.; Zhou X.-F.; Pei X.-F.; Zheng T.-L.; Zhong X.-N.; Li Q.; Ling H.; Wang D.-M.; Li S.-J.; He S.-S.; Li M.-F.; Li J.; Zhu X.; Ke C.-W.; Xiao H.; Di B.; Zhang Y.; Zhou H.-W.; Yu N.; Li H.-J.; Yang F.; Wang F.-X.; Wang J.; The Chinese Centers for Disease Control and Prevention (CDC) Etiology of Diarrhea Surveillance Study Team
发表日期	2021
ISSN	2041-1723
卷号	12 期号:1
英文摘要	National-based prospective surveillance of all-age patients with acute diarrhea was conducted in China between 2009‒2018. Here we report the etiological, epidemiological, and clinical features of the 152,792 eligible patients enrolled in this analysis. Rotavirus A and norovirus are the two leading viral pathogens detected in the patients, followed by adenovirus and astrovirus. Diarrheagenic Escherichia coli and nontyphoidal Salmonella are the two leading bacterial pathogens, followed by Shigella and Vibrio parahaemolyticus. Patients aged <5 years had higher overall positive rate of viral pathogens, while bacterial pathogens were more common in patients aged 18‒45 years. A joinpoint analysis revealed the age-specific positivity rate and how this varied for individual pathogens. Our findings fill crucial gaps of how the distributions of enteropathogens change across China in patients with diarrhea. This allows enhanced identification of the predominant diarrheal pathogen candidates for diagnosis in clinical practice and more targeted application of prevention and control measures. © 2021, The Author(s).
语种	英语
scopus关键词	diarrheal disease; epidemiology; etiology; identification method; pathogen; virus; acute diarrhea; Adenoviridae; adolescent; adult; Article; Astroviridae; bacterium detection; bacterium examination; child; China; clinical feature; clinical practice; controlled study; diarrheagenic Escherichia coli; Entamoeba histolytica; enzyme linked immunosorbent assay; female; Giardia intestinalis; human; incidence; infant; infectious diarrhea; major clinical study; male; middle aged; nonhuman; Norovirus; parasite examination; population density; reverse transcription polymerase chain reaction; Rotavirus A; Salmonella; seasonal variation; Shigella; Vibrio parahaemolyticus; virus detection; virus examination; age; calicivirus infection; diarrhea; Escherichia coli; Escherichia coli infection; gastroenteritis; isolation and purification; microbiology; pathology; preschool child; Rotavirus; Rotavirus infection; salmonellosis; vibriosis; young adult; China; Adenoviridae; Astroviridae; Bacteria (microorganisms); Escherichia coli; Norovirus; Rotavirus A; Salmonella; Shigella; Vibrio parahaemolyticus; Adolescent; Adult; Age Factors; Caliciviridae Infections; Child; Child, Preschool; China; Diarrhea; Escherichia coli; Escherichia coli Infections; Gastroenteritis; Humans; Middle Aged; Norovirus; Rotavirus; Rotavirus Infections; Salmonella; Salmonella Infections; Shigella; Vibrio Infections; Vibrio parahaemolyticus; Young Adult
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251465
作者单位	Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China; Anhui Medical University, Hefei, China; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China; National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, China; Sun Yat-sen University, Guangzhou, China; Yunnan Center for Disease Control and Prevention, Kunming, China; Shanghai Public Health Clinical Center, Shanghai, China; Zhejiang University, Hangzhou, China; Liaoning Provincial Center for Disease Control and Prevention, Shenyang, China; Gansu Provincial Center for Disease Control and Prevention, Lanzhou, China; Wuhan University, Wuhan, China; National Institute for Viral Disease Control and Preve...
推荐引用方式 GB/T 7714	Wang L.-P.,Zhou S.-X.,Wang X.,et al. Etiological, epidemiological, and clinical features of acute diarrhea in China[J],2021,12(1).
APA	Wang L.-P..,Zhou S.-X..,Wang X..,Lu Q.-B..,Shi L.-S..,...&The Chinese Centers for Disease Control and Prevention .(2021).Etiological, epidemiological, and clinical features of acute diarrhea in China.Nature Communications,12(1).
MLA	Wang L.-P.,et al."Etiological, epidemiological, and clinical features of acute diarrhea in China".Nature Communications 12.1(2021).