气候变化领域集成服务门户(CCPortal): Lying in wait: the resurgence of dengue virus after the Zika epidemic in Brazil

CCPortal

DOI	10.1038/s41467-021-22921-7
	Lying in wait: the resurgence of dengue virus after the Zika epidemic in Brazil
	Brito A.F.; Machado L.C.; Oidtman R.J.; Siconelli M.J.L.; Tran Q.M.; Fauver J.R.; Carvalho R.D.O.; Dezordi F.Z.; Pereira M.R.; de Castro-Jorge L.A.; Minto E.C.M.; Passos L.M.R.; Kalinich C.C.; Petrone M.E.; Allen E.; España G.C.; Huang A.T.; Cummings D.A.T.; Baele G.; Franca R.F.O.; da Fonseca B.A.L.; Perkins T.A.; Wallau G.L.; Grubaugh N.D.
发表日期	2021
ISSN	2041-1723
卷号	12 期号:1
英文摘要	After the Zika virus (ZIKV) epidemic in the Americas in 2016, both Zika and dengue incidence declined to record lows in many countries in 2017–2018, but in 2019 dengue resurged in Brazil, causing ~2.1 million cases. In this study we use epidemiological, climatological and genomic data to investigate dengue dynamics in recent years in Brazil. First, we estimate dengue virus force of infection (FOI) and model mosquito-borne transmission suitability since the early 2000s. Our estimates reveal that DENV transmission was low in 2017–2018, despite conditions being suitable for viral spread. Our study also shows a marked decline in dengue susceptibility between 2002 and 2019, which could explain the synchronous decline of dengue in the country, partially as a result of protective immunity from prior ZIKV and/or DENV infections. Furthermore, we performed phylogeographic analyses using 69 newly sequenced genomes of dengue virus serotype 1 and 2 from Brazil, and found that the outbreaks in 2018–2019 were caused by local DENV lineages that persisted for 5–10 years, circulating cryptically before and after the Zika epidemic. We hypothesize that DENV lineages may circulate at low transmission levels for many years, until local conditions are suitable for higher transmission, when they cause major outbreaks. © 2021, The Author(s).
语种	英语
scopus关键词	envelope protein; virus RNA; virus antibody; dengue fever; disease incidence; epidemic; epidemiology; genomics; phylogeography; Zika virus disease; Article; Brazil; chikungunya; dengue; Dengue virus; Dengue virus 1; Dengue virus 2; epidemic; epidemiological data; genome analysis; genomics; herd immunity; human; human tissue; immune response; incidence; metagenomics; molecular dynamics; mosquito; mosquito borne disease; phylogeography; public health; serotype; virus transmission; Zika fever; Zika virus; adolescent; adult; aged; child; dengue; Dengue virus; disease predisposition; epidemic; epidemiological monitoring; female; genetics; heterologous immunity; immunology; infant; isolation and purification; male; middle aged; molecular typing; mosquito vector; newborn; preschool child; serotyping; very elderly; virology; virus genome; young adult; Zika fever; Zika virus; Brazil; Dengue virus; Zika virus; Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Viral; Brazil; Child; Child, Preschool; Dengue; Dengue Virus; Disease Susceptibility; Epidemics; Epidemiological Monitoring; Female; Genome, Viral; Humans; Immunity, Heterologous; Incidence; Infant; Infant, Newborn; Male; Middle Aged; Molecular Typing; Mosquito Vectors; Phylogeography; Serotyping; Young Adult; Zika Virus; Zika Virus Infection
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251452
作者单位	Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, United States; Department of Entomology, Aggeu Magalhaẽs Institute, Fiocruz, Recife, PE, Brazil; Department of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States; Internal Medicine Department, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil; Department of Virology and Experimental Therapy, Aggeu Magalhaes Institute, Fiocruz, Recife, PE, Brazil; Municipal Health Secretary from Ribeirão Preto, Ribeirão Preto, SP, Brazil; Department of Biology and Emerging Pathogens Institute, University of Florida, Gainesville, FL, United States; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Evolutionary and Computational Virology, Leuven, Belgium; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, United States
推荐引用方式 GB/T 7714	Brito A.F.,Machado L.C.,Oidtman R.J.,et al. Lying in wait: the resurgence of dengue virus after the Zika epidemic in Brazil[J],2021,12(1).
APA	Brito A.F..,Machado L.C..,Oidtman R.J..,Siconelli M.J.L..,Tran Q.M..,...&Grubaugh N.D..(2021).Lying in wait: the resurgence of dengue virus after the Zika epidemic in Brazil.Nature Communications,12(1).
MLA	Brito A.F.,et al."Lying in wait: the resurgence of dengue virus after the Zika epidemic in Brazil".Nature Communications 12.1(2021).