气候变化领域集成服务门户(CCPortal): The role of maternal preconception vitamin D status in human offspring sex ratio

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DOI	10.1038/s41467-021-23083-2
	The role of maternal preconception vitamin D status in human offspring sex ratio
	Purdue-Smithe A.C.; Kim K.; Nobles C.; Schisterman E.F.; Schliep K.C.; Perkins N.J.; Sjaarda L.A.; Freeman J.R.; Robinson S.L.; Radoc J.G.; Mills J.L.; Silver R.M.; Ye A.; Mumford S.L.
发表日期	2021
ISSN	2041-1723
卷号	12 期号:1
英文摘要	Evolutionary theory suggests that some animal species may experience shifts in their offspring sex ratio in response to maternal health and environmental conditions, and in some unfavorable conditions, females may be less likely to bear sons. Experimental data in both animals and humans indicate that maternal inflammation may disproportionately impact the viability of male conceptuses; however, it is unknown whether other factors associated with both pregnancy and inflammation, such as vitamin D status, are associated with the offspring sex ratio. Here, we show that among 1,228 women attempting pregnancy, preconception 25-hydroxyvitamin D concentrations are positively associated with the live birth of a male infant, with notably stronger associations among women with elevated high sensitivity C-reactive protein, a marker of systemic low-grade inflammation. Our findings suggest that vitamin D may mitigate maternal inflammation that would otherwise be detrimental to the implantation or survival of male conceptuses in utero. © 2021, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
语种	英语
scopus关键词	25 hydroxyvitamin D; acetylsalicylic acid; C reactive protein; placebo; vitamin D; 25-hydroxyvitamin D; C reactive protein; vitamin D; adult; alcohol consumption; Article; controlled study; echography; ectopic pregnancy; female; follow up; gestational age; human; infant; inflammation; live birth; low drug dose; major clinical study; male; maternal welfare; outcome assessment; physical activity; pregnancy; prepregnancy care; progeny; seasonal variation; sex ratio; waist hip ratio; blood; newborn; pathology; prenatal exposure; vitamin D deficiency; C-Reactive Protein; Female; Humans; Infant, Newborn; Inflammation; Live Birth; Male; Pregnancy; Prenatal Exposure Delayed Effects; Sex Ratio; Vitamin D; Vitamin D Deficiency
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251448
作者单位	Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States; Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, United States; Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States
推荐引用方式 GB/T 7714	Purdue-Smithe A.C.,Kim K.,Nobles C.,et al. The role of maternal preconception vitamin D status in human offspring sex ratio[J],2021,12(1).
APA	Purdue-Smithe A.C..,Kim K..,Nobles C..,Schisterman E.F..,Schliep K.C..,...&Mumford S.L..(2021).The role of maternal preconception vitamin D status in human offspring sex ratio.Nature Communications,12(1).
MLA	Purdue-Smithe A.C.,et al."The role of maternal preconception vitamin D status in human offspring sex ratio".Nature Communications 12.1(2021).