气候变化领域集成服务门户(CCPortal): Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis

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DOI	10.1038/s41467-021-23786-6
	Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis
	Friedrich T.; Oberkofler V.; Trindade I.; Altmann S.; Brzezinka K.; Lämke J.; Gorka M.; Kappel C.; Sokolowska E.; Skirycz A.; Graf A.; Bäurle I.
发表日期	2021
ISSN	2041-1723
卷号	12 期号:1
英文摘要	Adaptive plasticity in stress responses is a key element of plant survival strategies. For instance, moderate heat stress (HS) primes a plant to acquire thermotolerance, which allows subsequent survival of more severe HS conditions. Acquired thermotolerance is actively maintained over several days (HS memory) and involves the sustained induction of memory-related genes. Here we show that FORGETTER3/ HEAT SHOCK TRANSCRIPTION FACTOR A3 (FGT3/HSFA3) is specifically required for physiological HS memory and maintaining high memory-gene expression during the days following a HS exposure. HSFA3 mediates HS memory by direct transcriptional activation of memory-related genes after return to normal growth temperatures. HSFA3 binds HSFA2, and in vivo both proteins form heteromeric complexes with additional HSFs. Our results indicate that only complexes containing both HSFA2 and HSFA3 efficiently promote transcriptional memory by positively influencing histone H3 lysine 4 (H3K4) hyper-methylation. In summary, our work defines the major HSF complex controlling transcriptional memory and elucidates the in vivo dynamics of HSF complexes during somatic stress memory. © 2021, The Author(s).
语种	英语
scopus关键词	heat shock transcription factor; heat shock transcription factor a2; heat shock transcription factor a3; histone H3; lysine; unclassified drug; Arabidopsis protein; heat shock transcription factor; histone; HSFA2 protein, Arabidopsis; HSFA3 protein, Arabidopsis; lysine; messenger RNA; multiprotein complex; protein binding; activation energy; gene expression; membrane; memory; methylation; physiology; protein; survival; temperature tolerance; Arabidopsis thaliana; Article; forgetter3 gene; gene; gene expression; heat stress; heterooligomerization; histone methylation; in vivo study; memory; nonhuman; phenotype; protein binding; temperature; transcription initiation; Arabidopsis; epistasis; gene expression regulation; gene locus; genetic transcription; genetics; heat shock response; kinetics; metabolism; methylation; physiology; plant gene; promoter region; transgenic plant; Arabidopsis; Arabidopsis; Arabidopsis Proteins; Epistasis, Genetic; Gene Expression Regulation, Plant; Genes, Plant; Genetic Loci; Heat Shock Transcription Factors; Heat-Shock Response; Histones; Kinetics; Lysine; Methylation; Multiprotein Complexes; Plants, Genetically Modified; Promoter Regions, Genetic; Protein Binding; RNA, Messenger; Transcription, Genetic
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251422
作者单位	Institute for Biochemistry and Biology, University of Potsdam, Potsdam, Germany; Max-Planck-Institute for Molecular Plant Physiology, Potsdam, Germany; School of Life Sciences, University of Dundee, Dundee, United Kingdom
推荐引用方式 GB/T 7714	Friedrich T.,Oberkofler V.,Trindade I.,et al. Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis[J],2021,12(1).
APA	Friedrich T..,Oberkofler V..,Trindade I..,Altmann S..,Brzezinka K..,...&Bäurle I..(2021).Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis.Nature Communications,12(1).
MLA	Friedrich T.,et al."Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis".Nature Communications 12.1(2021).