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DOI	10.1038/s41467-021-24396-y
	Timing the evolution of antioxidant enzymes in cyanobacteria
	Boden J.S.; Konhauser K.O.; Robbins L.J.; Sánchez-Baracaldo P.
发表日期	2021
ISSN	2041-1723
卷号	12 期号:1
英文摘要	The ancestors of cyanobacteria generated Earth’s first biogenic molecular oxygen, but how they dealt with oxidative stress remains unconstrained. Here we investigate when superoxide dismutase enzymes (SODs) capable of removing superoxide free radicals evolved and estimate when Cyanobacteria originated. Our Bayesian molecular clocks, calibrated with microfossils, predict that stem Cyanobacteria arose 3300–3600 million years ago. Shortly afterwards, we find phylogenetic evidence that ancestral cyanobacteria used SODs with copper and zinc cofactors (CuZnSOD) during the Archaean. By the Paleoproterozoic, they became genetically capable of using iron, nickel, and manganese as cofactors (FeSOD, NiSOD, and MnSOD respectively). The evolution of NiSOD is particularly intriguing because it corresponds with cyanobacteria’s invasion of the open ocean. Our analyses of metalloenzymes dealing with reactive oxygen species (ROS) now demonstrate that marine geochemical records alone may not predict patterns of metal usage by phototrophs from freshwater and terrestrial habitats. © 2021, Crown.
语种	英语
scopus关键词	antioxidant; copper zinc superoxide dismutase; free radical; iron superoxide dismutase; manganese superoxide dismutase; reactive oxygen metabolite; superoxide dismutase; zinc; antioxidant; copper; fresh water; iron; manganese; nickel; reactive oxygen metabolite; superoxide; superoxide dismutase; zinc; antioxidant; enzyme; enzyme activity; oxidative stress; phylogenetics; reactive oxygen species; Article; controlled study; cyanobacterium; microfossil; molecular clock; nonhuman; oxidative stress; Paleoproterozoic; phototroph; phylogeny; Bayes theorem; chemistry; coenzyme; cyanobacterium; enzymology; genetics; metabolism; molecular evolution; Cyanobacteria; Antioxidants; Bayes Theorem; Coenzymes; Copper; Cyanobacteria; Evolution, Molecular; Fresh Water; Iron; Manganese; Nickel; Oxidative Stress; Phylogeny; Reactive Oxygen Species; Superoxide Dismutase; Superoxides; Zinc
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251367
作者单位	School of Geographical Sciences, University of Bristol, Bristol, United Kingdom; Department of Earth and Atmospheric Sciences, University of Alberta, Edmonton, AB, Canada; Department of Earth and Planetary Sciences, Yale University, New Haven, CT, United States; Department of Geology, University of Regina, Regina, SK, Canada
推荐引用方式 GB/T 7714	Boden J.S.,Konhauser K.O.,Robbins L.J.,et al. Timing the evolution of antioxidant enzymes in cyanobacteria[J],2021,12(1).
APA	Boden J.S.,Konhauser K.O.,Robbins L.J.,&Sánchez-Baracaldo P..(2021).Timing the evolution of antioxidant enzymes in cyanobacteria.Nature Communications,12(1).
MLA	Boden J.S.,et al."Timing the evolution of antioxidant enzymes in cyanobacteria".Nature Communications 12.1(2021).