气候变化领域集成服务门户(CCPortal): The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas

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DOI	10.1038/s41467-021-26188-w
	The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas
	García-Ortiz H.; Barajas-Olmos F.; Contreras-Cubas C.; Cid-Soto M.Á.; Córdova E.J.; Centeno-Cruz F.; Mendoza-Caamal E.; Cicerón-Arellano I.; Flores-Huacuja M.; Baca P.; Bolnick D.A.; Snow M.; Flores-Martínez S.E.; Ortiz-Lopez R.; Reynolds A.W.; Blanchet A.; Morales-Marín M.; Velázquez-Cruz R.; Kostic A.D.; Galaviz-Hernández C.; García-Zapién A.G.; Jiménez-López J.C.; León-Reyes G.; Salas-Bautista E.G.; Lazalde-Ramos B.P.; Jiménez-Ruíz J.L.; Salas-Martínez G.; Ramos-Madrigal J.; Mirzaeicheshmeh E.; Saldaña-Alvarez Y.; del Carmen Abrahantes-Pérez M.; Loeza-Becerra F.; Mojica-Espinosa R.; Sánchez-Quinto F.; Rangel-Villalobos H.; Sosa-Macías M.; Sánchez-Corona J.; Rojas-Martinez A.; Martínez-Hernández A.; Orozco L.
发表日期	2021
ISSN	2041-1723
卷号	12 期号:1
英文摘要	The genetic makeup of Indigenous populations inhabiting Mexico has been strongly influenced by geography and demographic history. Here, we perform a genome-wide analysis of 716 newly genotyped individuals from 60 of the 68 recognized ethnic groups in Mexico. We show that the genetic structure of these populations is strongly influenced by geography, and our demographic reconstructions suggest a decline in the population size of all tested populations in the last 15–30 generations. We find evidence that Aridoamerican and Mesoamerican populations diverged roughly 4–9.9 ka, around the time when sedentary farming started in Mesoamerica. Comparisons with ancient genomes indicate that the Upward Sun River 1 (USR1) individual is an outgroup to Mexican/South American Indigenous populations, whereas Anzick-1 was more closely related to Mesoamerican/South American populations than to those from Aridoamerica, showing an even more complex history of divergence than recognized so far. © 2021, The Author(s).
语种	英语
scopus关键词	divergence; genetic structure; genomics; genotype; indigenous population; population decline; population size; adult; agricultural worker; article; demography; ethnic group; female; gene structure; human; human experiment; major clinical study; male; Mexico; population size; river; South American; sun; American Indian; classification; genetic variation; genetics; genomics; history; human genome; Mexico; migration; phylogeny; phylogeography; population dynamics; procedures; Mesoamerica; Mexico [North America]; Ethnic Groups; Genetic Variation; Genome, Human; Genomics; History, Ancient; Human Migration; Humans; Indians, North American; Mexico; Phylogeny; Phylogeography; Population Dynamics
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251339
作者单位	Instituto Nacional de Medicina Genómica, Tlalpan, Mexico City, Mexico; Department of Anthropology and Institute for Systems Genomics, University of Connecticut, Storrs, CT, United States; Department of Anthropology, University of Montana, Missoula, MT, United States; División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Mexico; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud. Universidad Autonoma de Nuevo Leon, Centro de Investigacion y Desarrollo en Ciencias de la Salud, Monterrey, Mexico; Department of Anthropology, Baylor University, Waco, TX, United States; Harvard Medical School, Joslin Diabetes Center, Boston, MA, United States; Instituto Politécnico Nacional, CIIDIR-Durango, Durango, Mexico; Departamento de Farmacobiología, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Guadalajara, Mexico; Dirección de Antropología Física, Instituto Nacional de Antropología ...
推荐引用方式 GB/T 7714	García-Ortiz H.,Barajas-Olmos F.,Contreras-Cubas C.,et al. The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas[J],2021,12(1).
APA	García-Ortiz H..,Barajas-Olmos F..,Contreras-Cubas C..,Cid-Soto M.Á..,Córdova E.J..,...&Orozco L..(2021).The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas.Nature Communications,12(1).
MLA	García-Ortiz H.,et al."The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas".Nature Communications 12.1(2021).