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DOI	10.1038/s41467-021-27091-0
	Molecular mechanisms and topological consequences of drastic chromosomal rearrangements of muntjac deer
	Yin Y.; Fan H.; Zhou B.; Hu Y.; Fan G.; Wang J.; Zhou F.; Nie W.; Zhang C.; Liu L.; Zhong Z.; Zhu W.; Liu G.; Lin Z.; Liu C.; Zhou J.; Huang G.; Li Z.; Yu J.; Zhang Y.; Yang Y.; Zhuo B.; Zhang B.; Chang J.; Qian H.; Peng Y.; Chen X.; Chen L.; Li Z.; Zhou Q.; Wang W.; Wei F.
发表日期	2021
ISSN	2041-1723
卷号	12 期号:1
英文摘要	Muntjac deer have experienced drastic karyotype changes during their speciation, making it an ideal model for studying mechanisms and functional consequences of mammalian chromosome evolution. Here we generated chromosome-level genomes for Hydropotes inermis (2n = 70), Muntiacus reevesi (2n = 46), female and male M. crinifrons (2n = 8/9) and a contig-level genome for M. gongshanensis (2n = 8/9). These high-quality genomes combined with Hi-C data allowed us to reveal the evolution of 3D chromatin architectures during mammalian chromosome evolution. We find that the chromosome fusion events of muntjac species did not alter the A/B compartment structure and topologically associated domains near the fusion sites, but new chromatin interactions were gradually established across the fusion sites. The recently borne neo-Y chromosome of M. crinifrons, which underwent male-specific inversions, has dramatically restructured chromatin compartments, recapitulating the early evolution of canonical mammalian Y chromosomes. We also reveal that a complex structure containing unique centromeric satellite, truncated telomeric and palindrome repeats might have mediated muntjacs’ recurrent chromosome fusions. These results provide insights into the recurrent chromosome tandem fusion in muntjacs, early evolution of mammalian sex chromosomes, and reveal how chromosome rearrangements can reshape the 3D chromatin regulatory conformations during species evolution. © 2021, The Author(s).
语种	英语
scopus关键词	chromosome; deer; genome; karyotype; molecular analysis; topology; Hydropotes inermis; Mammalia; Muntiacus; Muntiacus reevesi; animal; chromatin; chromosome; chromosome aberration; classification; contig mapping; deer; demography; female; genetics; genome; male; molecular evolution; muntjac; phylogeny; sex chromosome; synteny; veterinary medicine; Animals; Chromatin; Chromosome Aberrations; Chromosomes, Mammalian; Contig Mapping; Deer; Demography; Evolution, Molecular; Female; Genome; Male; Muntjacs; Phylogeny; Sex Chromosomes; Synteny
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251301
作者单位	School of Ecology and Environment, Northwestern Polytechnical University, Xi’an, 710072, China; CAS Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China; Center of Evolution and Conservation Biology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangdong, 511458, China; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China; BGI-Qingdao, BGI-Shenzhen, Qingdao, 266555, China; BGI-Shenzhen, Shenzhen, 518083, China; China National GeneBank, BGI-Shenzhen, Shenzhen, 518120, China; Kunming Cell Bank, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China; Frasergen Bioinformatics Co., Ltd, Wuhan, 430074, China; Beijing Milu Ecological Research Center, Bejing, 100076, China; Qianjiangyuan National Park, Kaihua, 324300, China; Department of Biotechnology and Biomedicine, ...
推荐引用方式 GB/T 7714	Yin Y.,Fan H.,Zhou B.,et al. Molecular mechanisms and topological consequences of drastic chromosomal rearrangements of muntjac deer[J],2021,12(1).
APA	Yin Y..,Fan H..,Zhou B..,Hu Y..,Fan G..,...&Wei F..(2021).Molecular mechanisms and topological consequences of drastic chromosomal rearrangements of muntjac deer.Nature Communications,12(1).
MLA	Yin Y.,et al."Molecular mechanisms and topological consequences of drastic chromosomal rearrangements of muntjac deer".Nature Communications 12.1(2021).