气候变化领域集成服务门户(CCPortal): Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains

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DOI	10.1038/s41467-021-27707-5
	Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains
	Nomura T.; Nagao K.; Shirai R.; Gotoh H.; Umeda M.; Ono K.
发表日期	2022
ISSN	2041-1723
卷号	13 期号:1
英文摘要	Ambient temperature significantly affects developmental timing in animals. The temperature sensitivity of embryogenesis is generally believed to be a consequence of the thermal dependency of cellular metabolism. However, the adaptive molecular mechanisms that respond to variations in temperature remain unclear. Here, we report species-specific thermal sensitivity of Notch signaling in the developing amniote brain. Transient hypothermic conditions increase canonical Notch activity and reduce neurogenesis in chick neural progenitors. Increased biosynthesis of phosphatidylethanolamine, a major glycerophospholipid components of the plasma membrane, mediates hypothermia-induced Notch activation. Furthermore, the species-specific thermal dependency of Notch signaling is associated with developmental robustness to altered Notch signaling. Our results reveal unique regulatory mechanisms for temperature-dependent neurogenic potentials that underlie developmental and evolutionary adaptations to a range of ambient temperatures in amniotes. © 2022, The Author(s).
语种	英语
scopus关键词	biological development; brain; cell component; lipid; metabolism; plasma; temperature effect; isoprotein; Notch1 receptor; phosphatidylethanolamine; protein Jagged 1; transcription factor HES 1; animal; biosynthesis; body temperature; cell membrane; chick embryo; chicken; cytology; embryo development; gene expression regulation; genetics; growth, development and aging; Institute for Cancer Research mouse; mammalian embryo; metabolism; mouse; neocortex; nerve cell; signal transduction; species difference; temperature; turtle; Animals; Body Temperature; Cell Membrane; Chick Embryo; Chickens; Embryo, Mammalian; Embryonic Development; Gene Expression Regulation, Developmental; Jagged-1 Protein; Mice; Mice, Inbred ICR; Neocortex; Neurons; Phosphatidylethanolamines; Protein Isoforms; Receptor, Notch1; Signal Transduction; Species Specificity; Temperature; Transcription Factor HES-1; Turtles
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251263
作者单位	Developmental Neurobiology, Kyoto Prefectural University of Medicine, INAMORI Memorial Building, 1-5 Shimogamo-Hangi cho, Kyoto, Sakyo-ku, 606-0823, Japan; Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto, Nishikyo-ku, 615-8510, Japan; Department of Biophysical Chemistry, Kyoto Pharmaceutical University, 5 Misasaginakauchi-cho, Kyoto, Yamashina-ku, 607-8414, Japan; School of Medicine, Niigata University, 757 Ichibancho, Asahimachi-dori, Chuo Ward, Niigata City, 951-8510, Japan; Japanese Red Cross Society Kyoto Daini Hospital, 355-5 Haru-obi cho, Marutamachi- noboru, Kamaza-dori, Kyoto, Kamigyo-ku, 602-8026, Japan; HOLO BIO Co., Ltd. 1-36 Goryo Ohara, Kyoto, Nichikyo-ku, 615-8245, Japan
推荐引用方式 GB/T 7714	Nomura T.,Nagao K.,Shirai R.,et al. Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains[J],2022,13(1).
APA	Nomura T.,Nagao K.,Shirai R.,Gotoh H.,Umeda M.,&Ono K..(2022).Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains.Nature Communications,13(1).
MLA	Nomura T.,et al."Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains".Nature Communications 13.1(2022).