气候变化领域集成服务门户(CCPortal): Discovery of a body-wide photosensory array that matures in an adult-like animal and mediates eye-brain-independent movement and arousal

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DOI	10.1073/PNAS.2021426118
	Discovery of a body-wide photosensory array that matures in an adult-like animal and mediates eye-brain-independent movement and arousal
	Shettigar N.; Chakravarthy A.; Umashankar S.; Lakshmanan V.; Palakodeti D.; Gulyani A.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:20
英文摘要	The ability to respond to light has profoundly shaped life. Animals with eyes overwhelmingly rely on their visual circuits for mediating light-induced coordinated movements. Building on previously reported behaviors, we report the discovery of an organized, eyeindependent (extraocular), body-wide photosensory framework that allows even a head-removed animal to move like an intact animal. Despite possessing sensitive cerebral eyes and a centralized brain that controls most behaviors, head-removed planarians show acute, coordinated ultraviolet-A (UV-A) aversive phototaxis. We find this eye-brain-independent phototaxis is mediated by two noncanonical rhabdomeric opsins, the first known function for this newly classified opsin-clade. We uncover a unique array of dualopsin- expressing photoreceptor cells that line the periphery of animal body, are proximal to a body-wide nerve net, and mediate UVA phototaxis by engaging multiple modes of locomotion. Unlike embryonically developing cerebral eyes that are functional when animals hatch, the body-wide photosensory array matures postembryonically in "adult-like animals." Notably, apart from headremoved phototaxis, the body-wide, extraocular sensory organization also impacts physiology of intact animals. Low-dose UV-A, but not visible light (ocular-stimulus), is able to arouse intact worms that have naturally cycled to an inactive/rest-like state. This wavelength selective, low-light arousal of resting animals is noncanonical-opsin dependent but eye independent. Our discovery of an autonomous, multifunctional, late-maturing, organized body-wide photosensory system establishes a paradigm in sensory biology and evolution oflight sensing. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Extraocular photoreception; Light-sensing; Opsins; Planarians; UV-A
语种	英语
scopus关键词	opsin; helminth protein; opsin; adult; arousal; Article; body wide photosensory array; Caenorhabditis elegans; controlled study; Drosophila; extraocular photoreception; fluorescence in situ hybridization; immunohistochemistry; nonhuman; photoreceptor; photoreceptor cell; phototaxis; protein expression; radiation dose; RNA interference; Schmidtea mediterranea; sensory system; ultraviolet A radiation; whole mount fluorescence in situ hybridization; animal; arousal; brain; classification; eye; gene expression profiling; gene expression regulation; genetics; growth, development and aging; invertebrate photoreceptor cell; locomotion; metabolism; movement (physiology); phylogeny; physiology; procedures; radiation response; Turbellaria; ultraviolet radiation; Animals; Arousal; Brain; Eye; Gene Expression Profiling; Gene Expression Regulation, Developmental; Helminth Proteins; In Situ Hybridization, Fluorescence; Locomotion; Movement; Opsins; Photoreceptor Cells, Invertebrate; Phylogeny; Planarians; RNA Interference; Ultraviolet Rays
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251204
作者单位	Institute for Stem Cell Science and Regenerative Medicine, Bangalore, 560065, India; School of Chemical and Biotechnology (SCBT), Shanmugha Arts, Science, Technology and Research Academy (SASTRA) University, Thanjavur, 613401, India; Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, India
推荐引用方式 GB/T 7714	Shettigar N.,Chakravarthy A.,Umashankar S.,et al. Discovery of a body-wide photosensory array that matures in an adult-like animal and mediates eye-brain-independent movement and arousal[J],2021,118(20).
APA	Shettigar N.,Chakravarthy A.,Umashankar S.,Lakshmanan V.,Palakodeti D.,&Gulyani A..(2021).Discovery of a body-wide photosensory array that matures in an adult-like animal and mediates eye-brain-independent movement and arousal.Proceedings of the National Academy of Sciences of the United States of America,118(20).
MLA	Shettigar N.,et al."Discovery of a body-wide photosensory array that matures in an adult-like animal and mediates eye-brain-independent movement and arousal".Proceedings of the National Academy of Sciences of the United States of America 118.20(2021).