气候变化领域集成服务门户(CCPortal): Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation

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DOI	10.1073/pnas.2103304118
	Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation
	Embgenbroich M.; van der Zande H.J.P.; Hussaarts L.; Schulte-Schrepping J.; Pelgrom L.R.; García-Tardón N.; Schlautmann L.; Stoetzel I.; Händler K.; Lambooij J.M.; Zawistowska-Deniziak A.; Hoving L.; de Ruiter K.; Wijngaarden M.; Pijl H.; van Dijk K.W.; Everts B.; van Harmelen V.; Yazdanbakhsh M.; Schultze J.L.; Guigas B.; Burgdorf S.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:31
英文摘要	Proinflammatory activation of macrophages in metabolic tissues is critically important in the induction of obesity-induced metaflammation. Here, we demonstrate that the soluble mannose receptor (sMR) plays a direct functional role in both macrophage activation and metaflammation. We show that sMR binds CD45 on macrophages and inhibits its phosphatase activity, leading to an Src/Akt/ NF-κB-mediated cellular reprogramming toward an inflammatory phenotype both in vitro and in vivo. Remarkably, increased serum sMR levels were observed in obese mice and humans and directly correlated with body weight. Importantly, enhanced sMR levels increase serum proinflammatory cytokines, activate tissue macrophages, and promote insulin resistance. Altogether, our results reveal sMR as regulator of proinflammatory macrophage activation, which could constitute a therapeutic target for metaflammation and other hyperinflammatory diseases. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Immunometabolism; Macrophage; Mannose receptor; Metaflammation; Obesity
语种	英语
scopus关键词	cytokine; Fcmr protein, mouse; mannose receptor; membrane protein; animal; animal food; cell culture; chemistry; drug effect; gene expression regulation; genetics; inflammation; intestine flora; knockout mouse; lipid diet; macrophage; macrophage activation; male; metabolism; mouse; physiology; randomization; Animal Feed; Animals; Cells, Cultured; Cytokines; Diet, High-Fat; Gastrointestinal Microbiome; Gene Expression Regulation; Inflammation; Macrophage Activation; Macrophages; Male; Mannose Receptor; Membrane Proteins; Mice; Mice, Knockout; Random Allocation
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251092
作者单位	Cellular Immunology, Life and Medical Sciences Institute, University of Bonn, Bonn, 53115, Germany; Department of Parasitology, Leiden University Medical Center, Leiden, 2333ZA, Netherlands; Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, 53115, Germany; Platform for Single-Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases, University of Bonn, Bonn, 53115, Germany; Witold Stefanski Institute of Parasitology, Polish Academy of Sciences, Warsaw, 00-818, Poland; Department of Human Genetics, Leiden University Medical Center, Leiden, 2333 ZA, Netherlands; Department of Internal Medicine, Section Endocrinology, Leiden University Medical Center, Leiden, 2333 ZA, Netherlands
推荐引用方式 GB/T 7714	Embgenbroich M.,van der Zande H.J.P.,Hussaarts L.,et al. Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation[J],2021,118(31).
APA	Embgenbroich M..,van der Zande H.J.P..,Hussaarts L..,Schulte-Schrepping J..,Pelgrom L.R..,...&Burgdorf S..(2021).Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation.Proceedings of the National Academy of Sciences of the United States of America,118(31).
MLA	Embgenbroich M.,et al."Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation".Proceedings of the National Academy of Sciences of the United States of America 118.31(2021).