气候变化领域集成服务门户(CCPortal): Longer or shorter spines: Reciprocal trait evolution in stickleback via triallelic regulatory changes in Stanniocalcin2a

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DOI	10.1073/pnas.2100694118
	Longer or shorter spines: Reciprocal trait evolution in stickleback via triallelic regulatory changes in Stanniocalcin2a
	Roberts Kingman G.A.; Lee D.; Jones F.C.; Desmet D.; Bell M.A.; Kingsley D.M.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:31
英文摘要	Vertebrates have repeatedly modified skeletal structures to adapt to their environments. The threespine stickleback is an excellent system for studying skeletal modifications, as different wild populations have either increased or decreased the lengths of their prominent dorsal and pelvic spines in different freshwater environments. Here we identify a regulatory locus that has a major morphological effect on the length of stickleback dorsal and pelvic spines, which we term Maser (major spine enhancer). Maser maps in a closely linked supergene complex that controls multiple armor, feeding, and behavioral traits on chromosome IV. Natural alleles in Maser are differentiated between marine and freshwater sticklebacks; however, alleles found among freshwater populations are also differentiated, with distinct alleles found in short- and long-spined freshwater populations. The distinct freshwater alleles either increase or decrease expression of the bone growth inhibitor gene Stanniocalcin2a in developing spines, providing a simple genetic mechanism for either increasing or decreasing spine lengths in natural populations. Genomic surveys suggest many recurrently differentiated loci in sticklebacks are similarly specialized into three or more distinct alleles, providing multiple ancient standing variants in particular genes that may contribute to a range of phenotypes in different environments. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Multiallelic polymorphism; Regulatory evolution; Stanniocalcin; Stickleback spine length; Supergene
语种	英语
scopus关键词	fish protein; signal peptide; allele; animal; animal structures; evolution; female; gene expression regulation; genetics; genomics; genotype; growth, development and aging; male; metabolism; physiology; polymerase chain reaction; quantitative trait locus; Smegmamorpha; Alleles; Animal Structures; Animals; Biological Evolution; Female; Fish Proteins; Gene Expression Regulation, Developmental; Genomics; Genotype; Intercellular Signaling Peptides and Proteins; Male; Polymerase Chain Reaction; Quantitative Trait Loci; Smegmamorpha
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251088
作者单位	Department of Developmental Biology, Stanford University, School of Medicine, Stanford, CA 94305, United States; Stanford University, School of Humanities and Sciences, Stanford University, Stanford, CA 94305, United States; University of California Museum of Paleontology, University of California, Berkeley, CA 94720, United States; HHMI, Stanford University, School of Medicine, Stanford, CA 94305, United States; Friedrich Miescher Laboratory of the Max Planck Society, Tübingen, 72076, Germany; Division of Research and Development, Upside Foods, Berkeley, CA 94710, United States
推荐引用方式 GB/T 7714	Roberts Kingman G.A.,Lee D.,Jones F.C.,et al. Longer or shorter spines: Reciprocal trait evolution in stickleback via triallelic regulatory changes in Stanniocalcin2a[J],2021,118(31).
APA	Roberts Kingman G.A.,Lee D.,Jones F.C.,Desmet D.,Bell M.A.,&Kingsley D.M..(2021).Longer or shorter spines: Reciprocal trait evolution in stickleback via triallelic regulatory changes in Stanniocalcin2a.Proceedings of the National Academy of Sciences of the United States of America,118(31).
MLA	Roberts Kingman G.A.,et al."Longer or shorter spines: Reciprocal trait evolution in stickleback via triallelic regulatory changes in Stanniocalcin2a".Proceedings of the National Academy of Sciences of the United States of America 118.31(2021).