气候变化领域集成服务门户(CCPortal): CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer

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DOI	10.1073/pnas.2012881118
	CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer
	Wang X.; Li J.; Bian X.; Wu C.; Hua J.; Chang S.; Yu T.; Li H.; Li Y.; Hu S.; Shan G.; Lin W.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:33
英文摘要	Circular RNAs (circRNAs) have emerged as key regulators of human cancers, yet their modes of action in gastric cancer (GC) remain largely unknown. Here, we identified circURI1 back-spliced from exons 3 and 4 of unconventional prefoldin RPB5 interactor 1 (URI1) from circRNA profiling of five-paired human gastric and the corresponding nontumor adjacent specimens (paraGC). CircURI1 exhibits the significantly higher expression in GC compared with paraGC and inhibitory effects on cell migration and invasion in vitro and GC metastasis in vivo. Mechanistically, circURI1 directly interacts with heterogeneous nuclear ribonucleoprotein M (hnRNPM) to modulate alternative splicing of genes, involved in the process of cell migration, thus suppressing GC metastasis. Collectively, our study expands the current knowledge regarding the molecular mechanism of circRNA-mediated cancer metastasis via modulating alternative splicing. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Alternative splicing; CircURI1; Gastric cancer; HnRNPM; Metastasis
语种	英语
scopus关键词	heterogeneous nuclear ribonucleoprotein group M; transcription factor; unclassified drug; unconventional prefoldin RPB5 interactor 1; DNA directed RNA polymerase; heterogeneous nuclear ribonucleoprotein group M; HNRNPM protein, human; POLR2E protein, human; alternative RNA splicing; animal experiment; animal model; Article; biochemistry; cancer inhibition; cancer prevention; cell invasion; cell migration; CircURI1 gene; controlled study; exon; gene expression regulation; gene function; gene targeting; genetic association; in vitro study; in vivo study; male; mouse; nonhuman; protein protein interaction; RNA sequence; stomach cancer; tumor-related gene; upregulation; alternative RNA splicing; animal; cell proliferation; experimental neoplasm; genetics; human; metabolism; metastasis; nude mouse; physiology; stomach tumor; Alternative Splicing; Animals; Cell Proliferation; DNA-Directed RNA Polymerases; Gene Expression Regulation, Neoplastic; Heterogeneous-Nuclear Ribonucleoprotein Group M; Humans; Male; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasms, Experimental; RNA, Circular; Stomach Neoplasms
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251064
作者单位	High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China; University of Science and Technology of China, Hefei, 230026, China; Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China; High Magnetic Field Laboratory of Anhui Province, Hefei, 230031, China; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China; Department of Neurosurgery, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China
推荐引用方式 GB/T 7714	Wang X.,Li J.,Bian X.,et al. CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer[J],2021,118(33).
APA	Wang X..,Li J..,Bian X..,Wu C..,Hua J..,...&Lin W..(2021).CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer.Proceedings of the National Academy of Sciences of the United States of America,118(33).
MLA	Wang X.,et al."CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer".Proceedings of the National Academy of Sciences of the United States of America 118.33(2021).