气候变化领域集成服务门户(CCPortal): Genome accessibility dynamics in response to phosphate limitation is controlled by the PHR1 family of transcription factors in Arabidopsis

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DOI	10.1073/pnas.2107558118
	Genome accessibility dynamics in response to phosphate limitation is controlled by the PHR1 family of transcription factors in Arabidopsis
	Barragán-Rosillo A.C.; Peralta-Alvarez C.A.; Ojeda-Rivera J.O.; Arzate-Mejía R.G.; Recillas-Targa F.; Herrera-Estrella L.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:33
英文摘要	As phosphorus is one of the most limiting nutrients in many natural and agricultural ecosystems, plants have evolved strategies that cope with its scarcity. Genetic approaches have facilitated the identification of several molecular elements that regulate the phosphate (Pi) starvation response (PSR) of plants, including the master regulator of the transcriptional response to phosphate starvation PHOSPHATE STARVATION RESPONSE1 (PHR1). However, the chromatin modifications underlying the plant transcriptional response to phosphate scarcity remain largely unknown. Here, we present a detailed analysis of changes in chromatin accessibility during phosphate starvation in Arabidopsis thaliana root cells. Root cells undergo a genome-wide remodeling of chromatin accessibility in response to Pi starvation that is often associated with changes in the transcription of neighboring genes. Analysis of chromatin accessibility in the phr1 phl2 double mutant revealed that the transcription factors PHR1 and PHL2 play a key role in remodeling chromatin accessibility in response to Pi limitation. We also discovered that PHR1 and PHL2 play an important role in determining chromatin accessibility and the associated transcription of many genes under optimal Pi conditions, including genes involved in the PSR. We propose that a set of transcription factors directly activated by PHR1 in Pi-starved root cells trigger a second wave of epigenetic changes required for the transcriptional activation of the complete set of low-Pi-responsive genes. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Chromatin; Chromatin accessibility; Epigenetics; Phosphate starvation
语种	英语
scopus关键词	phosphate; protein PHL2; protein PHR1; transcription factor; unclassified drug; Arabidopsis protein; phosphate; PHR1 protein, Arabidopsis; transcription factor; Arabidopsis thaliana; Article; chromatin assembly and disassembly; epigenetics; genome-wide association study; nonhuman; phl2 gene; phr1 gene; plant gene; plant genetics; plant nutrition; root cell; starvation; transcription initiation; Arabidopsis; chromatin; cytology; drug effect; gene expression regulation; genetics; metabolism; plant genome; plant root; Arabidopsis; Arabidopsis Proteins; Chromatin; Gene Expression Regulation, Plant; Genome, Plant; Phosphates; Plant Roots; Transcription Factors
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251059
作者单位	Laboratorio Nacional de Genómica para la Biodiversidad, Unidad de Genómica Avanzada, Centro de Investigación y Estudios Avanzados del Intituto Politecnico Nacional, Irapuato, 36500, Mexico; Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico; Institute of Genomics for Crop Abiotic Stress Tolerance, Department of Plant and Soil Science, Texas Tech University, Lubbock, TX 79430, United States
推荐引用方式 GB/T 7714	Barragán-Rosillo A.C.,Peralta-Alvarez C.A.,Ojeda-Rivera J.O.,et al. Genome accessibility dynamics in response to phosphate limitation is controlled by the PHR1 family of transcription factors in Arabidopsis[J],2021,118(33).
APA	Barragán-Rosillo A.C.,Peralta-Alvarez C.A.,Ojeda-Rivera J.O.,Arzate-Mejía R.G.,Recillas-Targa F.,&Herrera-Estrella L..(2021).Genome accessibility dynamics in response to phosphate limitation is controlled by the PHR1 family of transcription factors in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America,118(33).
MLA	Barragán-Rosillo A.C.,et al."Genome accessibility dynamics in response to phosphate limitation is controlled by the PHR1 family of transcription factors in Arabidopsis".Proceedings of the National Academy of Sciences of the United States of America 118.33(2021).