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DOI | 10.1073/pnas.2106048118 |
The transcription regulator BrsR serves as a network hub of natural competence protein-protein interactions in Streptococcus mutans | |
Qin H.; Zou Z.; Anderson D.; Sang Y.; Higashi D.; Kreth J.; Merritt J. | |
发表日期 | 2021 |
ISSN | 0027-8424 |
卷号 | 118期号:39 |
英文摘要 | Genome evolution is an essential and stringently regulated aspect of biological fitness. For bacteria, natural competence is one of the principal mechanisms of genome evolution and is frequently subject to multiple layers of regulation derived from a plethora of environmental and physiological stimuli. Here, we present a regulatory mechanism that illustrates how such disparate stimuli can be integrated into the Streptococcus mutans natural competence phenotype. S. mutans possesses an intriguing, but poorly understood ability to coordinately control its independently regulated natural competence and bacteriocin genetic pathways as a means to acquire DNA released from closely related, bacteriocinsusceptible streptococci. Our results reveal how the bacteriocinspecific transcription activator BrsR directly mediates this coordination by serving as an anti-adaptor protein responsible for antagonizing the proteolysis of the inherently unstable, natural competence-specific alternative sigma factor ComX. This BrsR ability functions entirely independent of its transcription regulator function and directly modulates the timing and severity of the natural competence phenotype. Additionally, many of the DNA uptake proteins produced by the competence system were surprisingly found to possess adaptor abilities, which are employed to terminate the BrsR regulatory circuit via negative feedback. BrsR- competence protein heteromeric complexes directly inhibit nascent brsR transcription as well as stimulate the Clp-dependent proteolysis of extant BrsR proteins. This study illustrates how critical genetic regulatory abilities can evolve in a potentially limitless variety of proteins without disrupting their conserved ancestral functions. These unrecognized regulatory abilities are likely fundamental for transducing information through complex genetic networks. © 2021 National Academy of Sciences. All rights reserved. |
英文关键词 | Bacteriocin; Gene regulation; Genetic networks; Natural competence; Protein-protein interactions |
语种 | 英语 |
scopus关键词 | bacterial protein; bacteriocin; transcription factor; gene expression regulation; genetics; growth, development and aging; metabolism; protein analysis; Streptococcus mutans; Bacterial Proteins; Bacteriocins; Gene Expression Regulation, Bacterial; Protein Interaction Maps; Streptococcus mutans; Transcription Factors |
来源期刊 | Proceedings of the National Academy of Sciences of the United States of America
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文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/251013 |
作者单位 | Department of Restorative Dentistry, Oregon Health and Science University, Portland, OR 97239, United States; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, United States |
推荐引用方式 GB/T 7714 | Qin H.,Zou Z.,Anderson D.,et al. The transcription regulator BrsR serves as a network hub of natural competence protein-protein interactions in Streptococcus mutans[J],2021,118(39). |
APA | Qin H..,Zou Z..,Anderson D..,Sang Y..,Higashi D..,...&Merritt J..(2021).The transcription regulator BrsR serves as a network hub of natural competence protein-protein interactions in Streptococcus mutans.Proceedings of the National Academy of Sciences of the United States of America,118(39). |
MLA | Qin H.,et al."The transcription regulator BrsR serves as a network hub of natural competence protein-protein interactions in Streptococcus mutans".Proceedings of the National Academy of Sciences of the United States of America 118.39(2021). |
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