气候变化领域集成服务门户(CCPortal): Elongin functions as a loading factor for Mediator at ATF6α-regulated ER stress response genes

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DOI	10.1073/pnas.2108751118
	Elongin functions as a loading factor for Mediator at ATF6α-regulated ER stress response genes
	He Y.; Sato S.; Tomomori-Sato C.; Chen S.; Goode Z.H.; Conaway J.W.; Conaway R.C.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:39
英文摘要	The bZIP transcription factor ATF6α is a master regulator of endoplasmic reticulum (ER) stress response genes. In this report, we identify the multifunctional RNA polymerase II transcription factor Elongin as a cofactor for ATF6α-dependent transcription activation. Biochemical studies reveal that Elongin functions at least in part by facilitating ATF6α-dependent loading of Mediator at the promoters and enhancers of ER stress response genes. Depletion of Elongin from cells leads to impaired transcription of ER stress response genes and to defects in the recruitment of Mediator and its CDK8 kinase subunit. Taken together, these findings bring to light a role for Elongin as a loading factor for Mediator during the ER stress response. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Enhancer; Mediator; RNA polymerase II; Transcription
语种	英语
scopus关键词	activating transcription factor 6; elongin; MED23 protein, human; MED26 protein, human; mediator complex; RNA polymerase II; animal; endoplasmic reticulum; endoplasmic reticulum stress; gene expression regulation; genetics; HeLa cell line; human; metabolism; pathology; promoter region; rat; signal transduction; transcription initiation; Activating Transcription Factor 6; Animals; Elongin; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Gene Expression Regulation; HeLa Cells; Humans; Mediator Complex; Promoter Regions, Genetic; Rats; RNA Polymerase II; Signal Transduction; Transcriptional Activation
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251012
作者单位	Stowers Institute for Medical Research, Kansas City, MO 64110, United States; Department of Biochemistry and Molecular Biology, Kansas University Medical Center, Kansas City, KS 66160, United States
推荐引用方式 GB/T 7714	He Y.,Sato S.,Tomomori-Sato C.,et al. Elongin functions as a loading factor for Mediator at ATF6α-regulated ER stress response genes[J],2021,118(39).
APA	He Y..,Sato S..,Tomomori-Sato C..,Chen S..,Goode Z.H..,...&Conaway R.C..(2021).Elongin functions as a loading factor for Mediator at ATF6α-regulated ER stress response genes.Proceedings of the National Academy of Sciences of the United States of America,118(39).
MLA	He Y.,et al."Elongin functions as a loading factor for Mediator at ATF6α-regulated ER stress response genes".Proceedings of the National Academy of Sciences of the United States of America 118.39(2021).