气候变化领域集成服务门户(CCPortal): Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis

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DOI	10.1073/pnas.2115667118
	Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis
	Cheng Y.-J.; Shang G.-D.; Xu Z.-G.; Yu S.; Wu L.-Y.; Zhai D.; Tian S.-L.; Gao J.; Wang L.; Wang J.-W.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:46
英文摘要	What determines the rate at which a multicellular organism matures is a fundamental question in biology. In plants, the decline of miR156 with age serves as an intrinsic, evolutionarily conserved timer for the juvenile-to-adult phase transition. However, the way in which age regulates miR156 abundance is poorly understood. Here, we show that the rate of decline in miR156 is correlated with developmental age rather than chronological age. Mechanistically, we found that cell division in the apical meristem is a trigger for miR156 decline. The transcriptional activity of MIR156 genes is gradually attenuated by the deposition of the repressive histone mark H3K27me3 along with cell division. Our findings thus provide a plausible explanation of why the maturation program of a multicellular organism is unidirectional and irreversible under normal growth conditions and suggest that cell quiescence is the fountain of youth in plants. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Age; Cell division; Developmental timing; miR156
语种	英语
scopus关键词	histone; microRNA; microRNA 156; unclassified drug; Arabidopsis protein; microRNA; transcription factor; aging; apical meristem; Arabidopsis; Article; cell division; cell maturation; developmental stage; genetic transcription; nonhuman; shoot; vegetative growth; cell division; gene expression regulation; genetics; meristem; plant leaf; shoot; transgenic plant; Arabidopsis; Arabidopsis Proteins; Cell Division; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Meristem; MicroRNAs; Plant Leaves; Plant Shoots; Plants, Genetically Modified; Transcription Factors
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/250985
作者单位	National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences (CEMPS), Institute of Plant Physiology and Ecology (SIPPE), Chinese Academy of Sciences (CAS), Shanghai, 200032, China; University of Chinese Academy of Sciences, Shanghai, 200032, China; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China
推荐引用方式 GB/T 7714	Cheng Y.-J.,Shang G.-D.,Xu Z.-G.,et al. Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis[J],2021,118(46).
APA	Cheng Y.-J..,Shang G.-D..,Xu Z.-G..,Yu S..,Wu L.-Y..,...&Wang J.-W..(2021).Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America,118(46).
MLA	Cheng Y.-J.,et al."Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis".Proceedings of the National Academy of Sciences of the United States of America 118.46(2021).