气候变化领域集成服务门户(CCPortal): Unraveling the genotype by environment interaction in a thermosensitive fish with a polygenic sex determination system

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DOI	10.1073/pnas.2112660118
	Unraveling the genotype by environment interaction in a thermosensitive fish with a polygenic sex determination system
	Geffroy B.; Besson M.; Sánchez-Baizán N.; Clota F.; Goikoetxea A.; Sadoul B.; Ruelle F.; Blanc M.-O.; Parrinello H.; Hermet S.; Blondeau-Bidet E.; Pratlong M.; Piferrer F.; Vandeputte M.; Allal F.
发表日期	2021
ISSN	1091-6490
卷号	118 期号:50
英文摘要	In most animals, sex determination occurs at conception, when sex chromosomes are segregated following Mendelian laws. However, in multiple reptiles and fishes, this genetic sex can be overridden by external factors after fertilization or birth. In some species, the genetic sex may also be governed by multiple genes, further limiting our understanding of sex determination in such species. We used the European sea bass (Dicentrarchus labrax) as a model and combined genomic (using a single nucleotide polymorphism chip) and transcriptomic (RNA-Sequencing) approaches to thoroughly depict this polygenic sex determination system and its interaction with temperature. We estimated genetic sex tendency (eGST), defined as the estimated genetic liability to become a given sex under a liability threshold model for sex determination, which accurately predicts the future phenotypic sex. We found evidence that energetic pathways, concerning the regulation of lipids and glucose, are involved in sex determination and could explain why females tend to exhibit higher energy levels and improved growth compared to males. Besides, early exposure to high-temperature up-regulated sox3, followed by sox9a in individuals with intermediate eGST, but not in individuals showing highly female-biased eGST, providing the most parsimonious explanation for temperature-induced masculinization. This gonadal state was maintained likely by DNA methylation and the up-regulation of several genes involved in histone modifications, including jmjd1c Overall, we describe a sex determination system resulting from continuous genetic and environmental influences in an animal. Our results provide significant progress in our understanding of the mechanisms underlying temperature-induced masculinization in fish.
英文关键词	epigenetic; fish; genomics; sex determination; temperature
语种	英语
scopus关键词	histone; transcription factor Sox; animal; bass; body size; DNA methylation; energy metabolism; female; gene expression regulation; genetics; genotype; gonad; male; metabolism; multifactorial inheritance; physiology; reproducibility; sex determination process; temperature; thermoregulation; Animals; Bass; Body Size; Body Temperature Regulation; DNA Methylation; Energy Metabolism; Female; Gene Expression Regulation; Genotype; Gonads; Histones; Male; Multifactorial Inheritance; Reproducibility of Results; Sex Determination Processes; SOX Transcription Factors; Temperature
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/250930
作者单位	MARBEC Université de Montpellier, CNRS, Ifremer, IRD, Palavas-les-Flots, France;; SYSAAF, Station LPGP/INRAE, Rennes, 35042, France; AgroParisTech, Université Paris-Saclay, GABI, France; Institut de Ciències del Mar, Spanish National Research Council, Barcelona, Spain; MARBEC Université de Montpellier, CNRS, Ifremer, IRD, Palavas-les-Flots, France; ESE, Ecology and Ecosystem Health, Rennes, France; Laboratoire Service d'Expérimentations Aquacoles, Ifremer, Palavas-les-Flots, France; BCM, Université de Montpellier, CNRS, INSERM, Montpellier, France; MARBEC Université de Montpellier, CNRS, Ifremer, IRD, Montpellier, France
推荐引用方式 GB/T 7714	Geffroy B.,Besson M.,Sánchez-Baizán N.,et al. Unraveling the genotype by environment interaction in a thermosensitive fish with a polygenic sex determination system[J],2021,118(50).
APA	Geffroy B..,Besson M..,Sánchez-Baizán N..,Clota F..,Goikoetxea A..,...&Allal F..(2021).Unraveling the genotype by environment interaction in a thermosensitive fish with a polygenic sex determination system.Proceedings of the National Academy of Sciences of the United States of America,118(50).
MLA	Geffroy B.,et al."Unraveling the genotype by environment interaction in a thermosensitive fish with a polygenic sex determination system".Proceedings of the National Academy of Sciences of the United States of America 118.50(2021).