气候变化领域集成服务门户(CCPortal): Hobit confers tissue-dependent programs to type 1 innate lymphoid cells

CCPortal

DOI	10.1073/pnas.2117965118
	Hobit confers tissue-dependent programs to type 1 innate lymphoid cells
	Yomogida K.; Bigley T.M.; Trsan T.; Gilfillan S.; Cella M.; Yokoyama W.M.; Egawa T.; Colonna M.
发表日期	2021
ISSN	1091-6490
卷号	118 期号:50
英文摘要	Identification of type 1 innate lymphoid cells (ILC1s) has been problematic. The transcription factor Hobit encoded by Zfp683 has been proposed as a major driver of ILC1 programs. Using Zfp683 reporter mice, we showed that correlation of Hobit expression with ILC1s is tissue- and context-dependent. In liver and intestinal mucosa, Zfp683 expression correlated well with ILC1s; in salivary glands, Zfp683 was coexpressed with the natural killer (NK) master transcription factors Eomes and TCF1 in a unique cell population, which we call ILC1-like NK cells; during viral infection, Zfp683 was induced in conventional NK cells of spleen and liver. The impact of Zfp683 deletion on ILC1s and NK cells was also multifaceted, including a marked decrease in granzyme- and interferon-gamma (IFNγ)-producing ILC1s in the liver, slightly fewer ILC1s and more Eomes+ TCF1+ ILC1-like NK cells in salivary glands, and only reduced production of granzyme B by ILC1 in the intestinal mucosa. NK cell-mediated control of viral infection was unaffected. We conclude that Hobit has two major impacts on ILC1s: It sustains liver ILC1 numbers, while promoting ILC1 functional maturation in other tissues by controlling TCF1, Eomes, and granzyme expression.
英文关键词	Eomes; Hobit; innate lymphoid cells; liver; natural killer cells
语种	英语
scopus关键词	biological marker; Eomes protein, mouse; gamma interferon; granzyme; granzyme A, mouse; Gzmb protein, mouse; leukocyte antigen; membrane protein; small cytoplasmic RNA; T box transcription factor; transcription factor; Zfp683 protein, mouse; animal; cellular immunity; classification; gene deletion; gene expression regulation; genetics; innate immunity; liver; lymphocyte subpopulation; metabolism; mouse; physiology; Animals; Antigens, CD; Biomarkers; Gene Deletion; Gene Expression Regulation; Granzymes; Immunity, Cellular; Immunity, Innate; Interferon-gamma; Liver; Lymphocyte Subsets; Membrane Proteins; Mice; RNA, Small Cytoplasmic; RNA-Seq; T-Box Domain Proteins; Transcription Factors
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/250927
作者单位	Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110; Rheumatology Division, Washington University School of Medicine, St. Louis, MO 63110; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110
推荐引用方式 GB/T 7714	Yomogida K.,Bigley T.M.,Trsan T.,et al. Hobit confers tissue-dependent programs to type 1 innate lymphoid cells[J],2021,118(50).
APA	Yomogida K..,Bigley T.M..,Trsan T..,Gilfillan S..,Cella M..,...&Colonna M..(2021).Hobit confers tissue-dependent programs to type 1 innate lymphoid cells.Proceedings of the National Academy of Sciences of the United States of America,118(50).
MLA	Yomogida K.,et al."Hobit confers tissue-dependent programs to type 1 innate lymphoid cells".Proceedings of the National Academy of Sciences of the United States of America 118.50(2021).