气候变化领域集成服务门户(CCPortal): Darwinian genomics and diversity in the tree of life

CCPortal

DOI	10.1073/pnas.2115644119
	Darwinian genomics and diversity in the tree of life
	Stephan T.; Burgess S.M.; Cheng H.; Danko C.G.; Gill C.A.; Jarvis E.D.; Koepfli K.-P.; Koltes J.E.; Lyons E.; Ronald P.; Ryder O.A.; Schriml L.M.; Soltis P.; VandeWoude S.; Zhou H.; Ostrander E.A.; Karlsson E.K.
发表日期	2022
ISSN	0027-8424
卷号	119 期号:4
英文摘要	Genomics encompasses the entire tree of life, both extinct and extant, and the evolutionary processes that shape this diversity. To date, genomic research has focused on humans, a small number of agricultural species, and established laboratory models. Fewer than 18,000 of ∼2,000,000 eukaryotic species (<1%) have a representative genome sequence in GenBank, and only a fraction of these have ancillary information on genome structure, genetic variation, gene expression, epigenetic modifications, and population diversity. This imbalance reflects a perception that human studies are paramount in disease research. Yet understanding how genomes work, and how genetic variation shapes phenotypes, requires a broad view that embraces the vast diversity of life. We have the technology to collect massive and exquisitely detailed datasets about the world, but expertise is siloed into distinct fields. A new approach, integrating comparative genomics with cell and evolutionary biology, ecology, archaeology, anthropology, and conservation biology, is essential for understanding and protecting ourselves and our world. Here, we describe potential for scientific discovery when comparative genomics works in close collaboration with a broad range of fields as well as the technical, scientific, and social constraints that must be addressed. © 2022 National Academy of Sciences. All rights reserved.
英文关键词	Biodiversity; Comparative genomics; Evolution; Genomics; Natural models
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/250889
作者单位	National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20817, United States; Avian Disease and Oncology Laboratory, Agricultural Research Service, US Department of Agriculture, East Lansing, MI 48823, United States; Department of Biomedical Sciences, Baker Institute for Animal Health, Cornell University, Ithaca, NY 14850, United States; Department of Animal Science, Texas A&M University, College Station, TX 77843, United States; Laboratory of Neurogenetics of Language, The Rockefeller University, New York, NY 10065, United States; HHMI, Chevy Chase, MD 20815, United States; Smithsonian- Mason School of Conservation, George Mason University, Front Royal, VA 22630, United States; Smithsonian Conservation Biology Institute, National Zoological Park, Washington, DC 20008, United States; Department of Animal Science, Iowa State University, Ames, IA 50011, United States; School of Plant Sciences, BIO5 Institute, University of Arizona, Tucson, AZ 85721, United States; Dep...
推荐引用方式 GB/T 7714	Stephan T.,Burgess S.M.,Cheng H.,et al. Darwinian genomics and diversity in the tree of life[J],2022,119(4).
APA	Stephan T..,Burgess S.M..,Cheng H..,Danko C.G..,Gill C.A..,...&Karlsson E.K..(2022).Darwinian genomics and diversity in the tree of life.Proceedings of the National Academy of Sciences of the United States of America,119(4).
MLA	Stephan T.,et al."Darwinian genomics and diversity in the tree of life".Proceedings of the National Academy of Sciences of the United States of America 119.4(2022).