气候变化领域集成服务门户(CCPortal): Phylogenomics of a new fungal phylum reveals multiple waves of reductive evolution across Holomycota

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DOI	10.1038/s41467-021-25308-w
	Phylogenomics of a new fungal phylum reveals multiple waves of reductive evolution across Holomycota
	Galindo L.J.; López-García P.; Torruella G.; Karpov S.; Moreira D.
发表日期	2021
ISSN	2041-1723
卷号	12 期号:1
英文摘要	Compared to multicellular fungi and unicellular yeasts, unicellular fungi with free-living flagellated stages (zoospores) remain poorly known and their phylogenetic position is often unresolved. Recently, rRNA gene phylogenetic analyses of two atypical parasitic fungi with amoeboid zoospores and long kinetosomes, the sanchytrids Amoeboradix gromovi and Sanchytrium tribonematis, showed that they formed a monophyletic group without close affinity with known fungal clades. Here, we sequence single-cell genomes for both species to assess their phylogenetic position and evolution. Phylogenomic analyses using different protein datasets and a comprehensive taxon sampling result in an almost fully-resolved fungal tree, with Chytridiomycota as sister to all other fungi, and sanchytrids forming a well-supported, fast-evolving clade sister to Blastocladiomycota. Comparative genomic analyses across fungi and their allies (Holomycota) reveal an atypically reduced metabolic repertoire for sanchytrids. We infer three main independent flagellum losses from the distribution of over 60 flagellum-specific proteins across Holomycota. Based on sanchytrids’ phylogenetic position and unique traits, we propose the designation of a novel phylum, Sanchytriomycota. In addition, our results indicate that most of the hyphal morphogenesis gene repertoire of multicellular fungi had already evolved in early holomycotan lineages. © 2021, The Author(s).
语种	英语
scopus关键词	evolution; fungus; gene expression; genomics; morphogenesis; phylogenetics; protein; actin filament; Algae Amoeboradix gromovi; Article; Blastocladiomycota; Catenaria anguillulae; Chytridiomycetes; cladistics; comparative genomics; comparative study; Encephalitozoon cuniculi; evolution; flagellum; fungal genome; fungus; gene amplification; holomycota; micromanipulation; Microsporidia; multigene family; new species; nonhuman; Nosema; Nosema parisii; Opisthokonta; Paramicrosporidium saccamoebae; phylogenetic tree; phylogenomics; phylogeny; phylum; Rozella allomycis; Sanchytriomycota; Sanchytrium tribonematis; taxon; whole genome sequencing; classification; cytology; fungus; fungus hyphae; genetics; genomics; kinetosome; liverwort; metabolism; phenotype; phylogeny; specimen handling; Chytridiomycota; Protofungi; transcriptome; Basal Bodies; Blastocladiomycota; Chytridiomycota; Flagella; Fungi; Genomics; Hepatophyta; Hyphae; Phenotype; Phylogeny; Specimen Handling; Transcriptome
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/250633
作者单位	Ecologie Systématique Evolution, CNRS, Université Paris-Saclay, AgroParisTech, Orsay, France; Zoological Institute, Russian Academy of Sciences, St. Petersburg, Russian Federation; St. Petersburg State University, St. Petersburg, Russian Federation
推荐引用方式 GB/T 7714	Galindo L.J.,López-García P.,Torruella G.,et al. Phylogenomics of a new fungal phylum reveals multiple waves of reductive evolution across Holomycota[J],2021,12(1).
APA	Galindo L.J.,López-García P.,Torruella G.,Karpov S.,&Moreira D..(2021).Phylogenomics of a new fungal phylum reveals multiple waves of reductive evolution across Holomycota.Nature Communications,12(1).
MLA	Galindo L.J.,et al."Phylogenomics of a new fungal phylum reveals multiple waves of reductive evolution across Holomycota".Nature Communications 12.1(2021).