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| DOI | 10.1038/s41467-021-26166-2 |
| Mapping epigenetic divergence in the massive radiation of Lake Malawi cichlid fishes | |
| Vernaz G.; Malinsky M.; Svardal H.; Du M.; Tyers A.M.; Santos M.E.; Durbin R.; Genner M.J.; Turner G.F.; Miska E.A. | |
| 发表日期 | 2021 |
| ISSN | 2041-1723 |
| 卷号 | 12期号:1 |
| 英文摘要 | Epigenetic variation modulates gene expression and can be heritable. However, knowledge of the contribution of epigenetic divergence to adaptive diversification in nature remains limited. The massive evolutionary radiation of Lake Malawi cichlid fishes displaying extensive phenotypic diversity despite extremely low sequence divergence is an excellent system to study the epigenomic contribution to adaptation. Here, we present a comparative genome-wide methylome and transcriptome study, focussing on liver and muscle tissues in phenotypically divergent cichlid species. In both tissues we find substantial methylome divergence among species. Differentially methylated regions (DMR), enriched in evolutionary young transposons, are associated with transcription changes of ecologically-relevant genes related to energy expenditure and lipid metabolism, pointing to a link between dietary ecology and methylome divergence. Unexpectedly, half of all species-specific DMRs are shared across tissues and are enriched in developmental genes, likely reflecting distinct epigenetic developmental programmes. Our study reveals substantial methylome divergence in closely-related cichlid fishes and represents a resource to study the role of epigenetics in species diversification. © 2021, Crown. |
| 语种 | 英语 |
| scopus关键词 | transcriptome; adaptive radiation; cichlid; divergence; gene expression; genetic analysis; mapping method; adaptive radiation; animal tissue; Article; Astatotilapia calliptera; Aulonocara stuartgranti; cichlid; developmental gene; Diplotaxodon limnothrissa; DNA methylation; DNA sequence; energy expenditure; epigenetics; gene mapping; genetic variability; lake; lipid metabolism; liver tissue; Malawi; Maylandia zebra; methylome; muscle tissue; nonhuman; Petrotilapia genalutea; Rhamphochromis longiceps; transposon; whole genome bisulfite sequencing; whole transcriptome sequencing; animal; chromosomal mapping; cichlid; gene expression; genetic epigenesis; genetics; genomics; liver; molecular evolution; species difference; East African Lakes; Lake Malawi; Cichlidae; Pisces; Animals; Chromosome Mapping; Cichlids; DNA Transposable Elements; Epigenesis, Genetic; Epigenome; Evolution, Molecular; Gene Expression; Genomics; Lakes; Liver; Malawi; Sequence Analysis, DNA; Species Specificity |
| 来源期刊 | Nature Communications
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/250603 |
| 作者单位 | Wellcome/CRUK Gurdon Institute, University of Cambridge, Cambridge, United Kingdom; Department of Genetics, University of Cambridge, Cambridge, United Kingdom; Wellcome Sanger Institute, Cambridge, United Kingdom; School of Natural Sciences, Sciences, Bangor University, Bangor, United Kingdom; Department of Zoology, University of Cambridge, Cambridge, United Kingdom; School of Biological Sciences, University of Bristol, Bristol, United Kingdom; Institute of Ecology and Evolution, University of Bern, Bern, Switzerland; Department of Biology, University of Antwerp, Antwerp, Belgium; Naturalis Biodiversity Center, Leiden, Netherlands; Max Planck Institute for Biology of Ageing, Cologne, Germany |
| 推荐引用方式 GB/T 7714 | Vernaz G.,Malinsky M.,Svardal H.,et al. Mapping epigenetic divergence in the massive radiation of Lake Malawi cichlid fishes[J],2021,12(1). |
| APA | Vernaz G..,Malinsky M..,Svardal H..,Du M..,Tyers A.M..,...&Miska E.A..(2021).Mapping epigenetic divergence in the massive radiation of Lake Malawi cichlid fishes.Nature Communications,12(1). |
| MLA | Vernaz G.,et al."Mapping epigenetic divergence in the massive radiation of Lake Malawi cichlid fishes".Nature Communications 12.1(2021). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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