气候变化领域集成服务门户(CCPortal): Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia

CCPortal

DOI	10.1038/s41467-021-26400-x
	Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia
	Walker J.S.; Hing Z.A.; Sher S.; Cronin J.; Williams K.; Harrington B.; Skinner J.N.; Cempre C.B.; Gregory C.T.; Pan A.; Yano M.; Beaver L.P.; Walker B.R.; Labanowska J.M.; Heerema N.A.; Mrózek K.; Woyach J.A.; Ruppert A.S.; Lehman A.; Ozer H.G.; Coppola V.; Yan P.; Byrd J.C.; Blachly J.S.; Lapalombella R.
发表日期	2021
ISSN	2041-1723
卷号	12 期号:1
英文摘要	Rare, recurrent balanced translocations occur in a variety of cancers but are often not functionally interrogated. Balanced translocations with the immunoglobulin heavy chain locus (IGH; 14q32) in chronic lymphocytic leukemia (CLL) are infrequent but have led to the discovery of pathogenic genes including CCND1, BCL2, and BCL3. Following identification of a t(X;14)(q28;q32) translocation that placed the mature T cell proliferation 1 gene (MTCP1) adjacent to the immunoglobulin locus in a CLL patient, we hypothesized that this gene may have previously unrecognized importance. Indeed, here we report overexpression of human MTCP1 restricted to the B cell compartment in mice produces a clonal CD5+/CD19+ leukemia recapitulating the major characteristics of human CLL and demonstrates favorable response to therapeutic intervention with ibrutinib. We reinforce the importance of genetic interrogation of rare, recurrent balanced translocations to identify cancer driving genes via the story of MTCP1 as a contributor to CLL pathogenesis. © 2021, The Author(s).
语种	英语
scopus关键词	antibody; cancer; cell component; gene expression; inhibition; integrated approach; translocation; BCL2 protein, human; BCL3 protein, human; CCND1 protein, human; cyclin D1; immunoglobulin heavy chain; MTCP1 protein, human; oncoprotein; protein bcl 2; adult; aged; animal; C57BL mouse; chronic lymphatic leukemia; female; gene expression regulation; gene translocation; genetics; human; immunoglobulin heavy chain gene; male; metabolism; middle aged; mouse; oncogene; very elderly; Adult; Aged; Aged, 80 and over; Animals; B-Cell Lymphoma 3 Protein; Cyclin D1; Female; Gene Expression Regulation; Genes, Immunoglobulin Heavy Chain; Humans; Immunoglobulin Heavy Chains; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Mice; Mice, Inbred C57BL; Middle Aged; Oncogenes; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Translocation, Genetic
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/250582
作者单位	Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, United States; Department of Pathology, The Ohio State University, Columbus, OH, United States; The Ohio State University Comprehensive Cancer Center, Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University, Columbus, OH, United States; Center for Biostatistics, The Ohio State University, Columbus, OH, United States; Department of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH, United States; Department of Cancer Biology and Genetics, The Ohio State University College of Medicine, Columbus, OH, United States; Genetically Engineered Mouse Modeling Core, The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, OH, United States; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbu...
推荐引用方式 GB/T 7714	Walker J.S.,Hing Z.A.,Sher S.,et al. Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia[J],2021,12(1).
APA	Walker J.S..,Hing Z.A..,Sher S..,Cronin J..,Williams K..,...&Lapalombella R..(2021).Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia.Nature Communications,12(1).
MLA	Walker J.S.,et al."Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia".Nature Communications 12.1(2021).