气候变化领域集成服务门户(CCPortal): Pathological damage, immune-related protein expression, and oxidative stress in lungs of BALB/c mice induced by haze PM2.5 biological components exposure

CCPortal

DOI	10.1016/j.atmosenv.2019.117230
	Pathological damage, immune-related protein expression, and oxidative stress in lungs of BALB/c mice induced by haze PM2.5 biological components exposure
	Wu B.; Dong Y.; Wang M.; Yang W.; Hu L.; Zhou D.; Lv J.; Chai T.
发表日期	2020
ISSN	1352-2310
卷号	223
英文摘要	Particulate matter (PM) pollution poses a huge public health threat, and exposure to haze pollution for short or long periods of time cause health problems. In this study, 16S rDNA and ITS high-throughput sequencing were used to analyze the microbial components of fine particulate matter (PM2.5) collected between December 20th and December 27th of 2016 during a severe haze in Tai'an, China. Although most inhalable microorganisms are not pathogenic to humans, we detected the presence of some types of bacteria that cause respiratory inflammation (such as Pseudomonas and Corynebacterium), allergic reactions (such as Alternaria), and lung inflammation (such as Nesterenkonia). Acute and chronic haze PM2.5 exposure experiments were conducted using BALB/c mice to gain insight about the harm these microbes may have on human health. Results indicate that acute exposure to haze PM2.5 can cause pathological lung damage, decrease the expressions of oxidative stress indicators T-AOC, SOD, and GSH-PX, increase the expression of MDA, and induce apoptosis. Furthermore, chronic exposure was found to cause more damage. Toll-like receptors can be used identify molecular patterns associated with microbial pathogens. The expression of TLR2 and TLR4 were increased in both single- and repeated-exposure groups, but they were significantly increased in the repeated-exposure group (P < 0.05). The role of biological components in PM in mediating inflammation and pathological damage should not be neglected. © 2019 Elsevier Ltd
关键词	Apoptosis Haze Immune related protein Oxidative stress Pathological pulmonary damage PM2.5
语种	英语
scopus关键词	Bacteria; Biological organs; Cell death; Health risks; Mammals; Oxidative stress; Pathology; Pollution; Proteins; Biological components; Fine particulate matter (PM2.5); Haze; High-throughput sequencing; Microbial components; Pathological damages; Pathological pulmonary damage; PM2.5; Particles (particulate matter); beta interferon; DNA 16S; glutathione peroxidase; interleukin 1beta; interleukin 6; macrophage inflammatory protein 1alpha; malonaldehyde; monocyte chemotactic protein 1; superoxide dismutase; toll like receptor 2; toll like receptor 4; transforming growth factor beta1; tumor necrosis factor; gene expression; haze; laboratory method; oxidative stress; particulate matter; pathology; pollution exposure; protein; public health; rodent; Acinetobacter; Acremonium; Actinobacteria; allergic reaction; Alternaria; animal experiment; animal model; animal tissue; apoptosis; Ascomycetes; Bacteroidetes; Chytridiomycetes; Citrobacter; controlled study; Corynebacterium; cyanobacterium; Enterococcus; Firmicutes; Fusobacteria; haze; heat treatment; high throughput sequencing; histopathology; Lactococcus; long term exposure; lung alveolus wall; lung injury; lymphocyte count; mouse; neutrophil count; nonhuman; Oscillospira; oxidative stress; particulate matter; Penicillium; pneumonia; priority journal; protein expression; Proteobacteria; Pseudomonas; Salmonella; Sarocladium; Streptococcus; Trichoderma; TUNEL assay; upregulation; Zygomycetes; China; Alternaria; Bacteria (microorganisms); Corynebacterium; Mus; Nesterenkonia; Pseudomonas
来源期刊	ATMOSPHERIC ENVIRONMENT
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/249386
作者单位	College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Key Laboratory of Animal Bioengineering and Animal Disease of Shandong Province, Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, 61 Daizong Road, Tai'an, Shandong Province 271000, China; Tai'an Municipal Center for Disease Control and Prevention, Tai'an, China; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, No. 20, Dongdajie, Fengtai, Beijing 100071, China
推荐引用方式 GB/T 7714	Wu B.,Dong Y.,Wang M.,et al. Pathological damage, immune-related protein expression, and oxidative stress in lungs of BALB/c mice induced by haze PM2.5 biological components exposure[J],2020,223.
APA	Wu B..,Dong Y..,Wang M..,Yang W..,Hu L..,...&Chai T..(2020).Pathological damage, immune-related protein expression, and oxidative stress in lungs of BALB/c mice induced by haze PM2.5 biological components exposure.ATMOSPHERIC ENVIRONMENT,223.
MLA	Wu B.,et al."Pathological damage, immune-related protein expression, and oxidative stress in lungs of BALB/c mice induced by haze PM2.5 biological components exposure".ATMOSPHERIC ENVIRONMENT 223(2020).