气候变化领域集成服务门户(CCPortal): Differential effects of fine and coarse particulate matter on hospitalizations for ischemic heart disease: A population-based time-series analysis in Southwestern China

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DOI	10.1016/j.atmosenv.2020.117366
	Differential effects of fine and coarse particulate matter on hospitalizations for ischemic heart disease: A population-based time-series analysis in Southwestern China
	Liu S.; Wang L.; Zhou L.; Li W.; Pu X.; Jiang J.; Chen Y.; Zhang L.; Qiu H.
发表日期	2020
ISSN	1352-2310
卷号	224
英文摘要	Few studies have explored the associations of ischemic heart disease (IHD) hospitalizations with fine (diameter ≤ 2.5 μm, PM2.5) and coarse particulate matter (diameter between 2.5 and 10 μm, PMC) simultaneously; and studies to distinguish the susceptible populations by sex, age, and comorbidity status are sparse and inconsistent. This study aimed to assess the differential effects of PM2.5 and PMC on IHD hospitalizations and to investigate modifiers of demographic characters, causes of hospitalizations, and comorbidity status on these differential effects. A time-series analysis using an over-dispersed generalized additive model on 33017 IHD hospitalizations was conducted in urban areas of Chengdu, Southwestern China, from 1 January 2015 to 31 December 2016. Z-test was used to test whether PMC- or PM2.5-related effects were differential within each modifier. Furthermore, to evaluate the robustness of the key findings for gaseous pollutants exposure adjustment, co-pollutant models were constructed. We identified differential effects of PM2.5 and PMC on IHD hospitalizations in terms of the effect magnitude, effect stability, and susceptible populations. A 10 μg/m³ increment of PM2.5 and PMC at lag06 was associated with a 1.2% (95% confidence interval (CI): 0.3%, 2.2%) and 2.5% (95%CI: 1.1%, 3.8%) increase in IHD hospitalizations, respectively. After adjustment for gaseous pollutants, PMC effect was independent, particularly among males, angina, chronic IHD, and patients with comorbidity of chronic heart failure, hypertension, or chronic obstructive pulmonary disease (COPD); whereas, PM2.5 effect remained significant among patients with comorbidity of hypertension. Males, comorbidity of hypertension or COPD substantially increased the PMC-related risk for IHD hospitalizations; whereas, only comorbidity of hypertension increased the PM2.5-related risk for IHD hospitalizations. Interestingly, the PMC effect was comparable between the middle-aged and the elderly. Our study found differential effects of PM2.5 and PMC on IHD hospitalizations and identified susceptible populations, which are important to establish guidelines or recommendations for high-risk individuals. © 2020 Elsevier Ltd
关键词	Coarse particulate matter Comorbidity Fine particulate matter Hospital admission Ischemic heart disease Susceptible population
语种	英语
scopus关键词	Cardiology; Epidemiology; Fog; Harmonic analysis; Heart; Particles (particulate matter); Pollution; Pulmonary diseases; Co morbidities; Coarse particulate matter; Fine particulate matter; Hospital admissions; Ischemic heart disease; Susceptible population; Time series analysis; chronic obstructive pulmonary disease; confidence interval; demography; hospital sector; hypertension; morbidity; particulate matter; pollution exposure; time series analysis; acute heart infarction; adult; aged; air pollutant; air pollution; angina pectoris; Article; cardiovascular risk; causality; China; chronic disease; chronic obstructive lung disease; comorbidity; comparative study; congestive heart failure; demography; diabetes mellitus; disease association; environmental exposure; female; gender; heart failure; high risk population; hospital admission; hospitalization; human; hypertension; ischemic heart disease; major clinical study; male; middle aged; particle size; particulate matter; population research; priority journal; susceptible population; time series analysis; urban area; Chengdu; China; Sichuan
来源期刊	ATMOSPHERIC ENVIRONMENT
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/249284
作者单位	Department of Operation and Administration, West China Hospital, Sichuan University, Chengdu, China; West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China; Big Data Research Center, University of Electronic Science and Technology of China, Chengdu, China; Health Information Center of Sichuan Province, Chengdu, China; Cardiology Division, West China Hospital, Sichuan University, Chengdu, China; School of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
推荐引用方式 GB/T 7714	Liu S.,Wang L.,Zhou L.,et al. Differential effects of fine and coarse particulate matter on hospitalizations for ischemic heart disease: A population-based time-series analysis in Southwestern China[J],2020,224.
APA	Liu S..,Wang L..,Zhou L..,Li W..,Pu X..,...&Qiu H..(2020).Differential effects of fine and coarse particulate matter on hospitalizations for ischemic heart disease: A population-based time-series analysis in Southwestern China.ATMOSPHERIC ENVIRONMENT,224.
MLA	Liu S.,et al."Differential effects of fine and coarse particulate matter on hospitalizations for ischemic heart disease: A population-based time-series analysis in Southwestern China".ATMOSPHERIC ENVIRONMENT 224(2020).