气候变化领域集成服务门户(CCPortal): Short-term exposure to nitrogen dioxide and outpatient visits for cause-specific conjunctivitis: A time-series study in Jinan, China

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DOI	10.1016/j.atmosenv.2021.118211
	Short-term exposure to nitrogen dioxide and outpatient visits for cause-specific conjunctivitis: A time-series study in Jinan, China
	Guo H.; Zhang S.; Zhang Z.; Zhang J.; Wang C.; Fang X.; Lin H.; Li H.; Ruan Z.
发表日期	2021
ISSN	1352-2310
卷号	247
英文摘要	Background: Though the conjunctiva are directly contacting with the atmospheric environment, the association between air pollution and conjunctival disease has not been well documented. Objective: To explore the association between ambient nitrogen dioxide (NO2) and daily outpatient visits for cause-specific conjunctivitis in Jinan, China. Methods: Daily concentrations of air pollution were obtained from the air quality sharing platform of China, and daily outpatient visits for conjunctivitis were collected from Qilu Hospital. The association between daily NO2 level and outpatient visits for conjunctivitis was examined by a generalized additive Poisson model, and stratified analyses by sex, age and season were further performed. Results: A total of 42,123 outpatient visits for conjunctivitis were recorded during 2014–2019, including 8504 infective conjunctivitis, 6429 allergic conjunctivitis and 27,190 unspecified conjunctivitis. Each 10 μg/m3 increase in NO2 was associated with a 1.00% (95% CI: 0.13%, 1.87%) increment in daily outpatient visits for conjunctivitis. Significant associations between NO2 and conjunctivitis were observed in the female population [excess risk, ER = 1.09% (95% CI: 0.05%, 2.15%)], in people aged 18–65 years [ER = 1.15% (95% CI: 0.15%, 2.15%)] and in cold season [ER = 1.67% (95% CI: 0.58%, 2.77%)]. Moreover, we also found significant associations of NO2 with infective conjunctivitis [ER = 2.60% (95% CI: 0.69%, 4.54%)], but not with allergic conjunctivitis [ER = −0.43% (95% CI: −2.38%, 1.56%)]and unspecified conjunctivitis [ER = 0.16% (95% CI: −0.96%, 1.29%)]. Conclusion: This study suggests that short-term exposure to NO2 might induce conjunctivitis, and air pollution control measures should be encouraged to keep ocular surface healthy. © 2021 Elsevier Ltd
关键词	Air pollution Conjunctivitis Nitrogen dioxide Short-term exposure Time-series
语种	英语
scopus关键词	Air quality; Nitrogen oxides; Allergic conjunctivitis; Ambient nitrogen dioxide; Atmospheric environment; Generalized additives; Nitrogen dioxides; Sharing platforms; Short-term exposure; Stratified analysis; Air pollution control; nitrogen dioxide; ozone; sulfur dioxide; adult; aged; air pollution; air quality; allergic conjunctivitis; ambient air; Article; China; cold; conjunctivitis; controlled study; environmental exposure; female; high temperature; human; humidity; infective conjunctivitis; major clinical study; male; meteorological phenomena; outpatient care; particulate matter; pathogenesis; priority journal; time series analysis
来源期刊	ATMOSPHERIC ENVIRONMENT
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/248604
作者单位	Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, 250012, China; Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China; Editorial Department for Chinese Journal of Preventive Medicine, Chinese Medical Association Publishing House, Beijing, 100052, China; Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, 230032, China; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China
推荐引用方式 GB/T 7714	Guo H.,Zhang S.,Zhang Z.,et al. Short-term exposure to nitrogen dioxide and outpatient visits for cause-specific conjunctivitis: A time-series study in Jinan, China[J],2021,247.
APA	Guo H..,Zhang S..,Zhang Z..,Zhang J..,Wang C..,...&Ruan Z..(2021).Short-term exposure to nitrogen dioxide and outpatient visits for cause-specific conjunctivitis: A time-series study in Jinan, China.ATMOSPHERIC ENVIRONMENT,247.
MLA	Guo H.,et al."Short-term exposure to nitrogen dioxide and outpatient visits for cause-specific conjunctivitis: A time-series study in Jinan, China".ATMOSPHERIC ENVIRONMENT 247(2021).