气候变化领域集成服务门户(CCPortal): Association between short-term exposure to air pollution and peptic ulcer bleeding: A case-crossover study in China

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DOI	10.1016/j.atmosenv.2021.118438
	Association between short-term exposure to air pollution and peptic ulcer bleeding: A case-crossover study in China
	Wu M.; Tang M.; Yu Z.; Mao X.; Chen Y.; Wang J.; Jin M.; Yu C.; Chen K.
发表日期	2021
ISSN	1352-2310
卷号	256
英文摘要	Background: Air pollution has already become a serious public health concern worldwide, while evidence for the association between air pollution and digestive disease is not consistent. Objective: To examine the association between air pollution and peptic ulcer bleeding (PUB). Methods: We performed a time-stratified case-crossover study among 1,246,270 gastroscopy records in Zhejiang, China from January 1st, 2013 to June 30th, 2019. Individual exposure to air pollution for each subject was estimated by using data from 55 fixed-sites with an inverse distance weighted method. Conditional logistic regression models were used to estimate the odds ratios (ORs) and 95% confidence intervals (95% CIs) for PUB associated with an interquartile range (IQR) increase in air pollution on the entire population. Subgroup analyses were performed for season, age and sex. Results: Totally 3543 patients diagnosed with PUB were included in the analyses. Significant associations were observed between NO2, CO and PM2.5 and the risk of PUB. The effect was observed strongest measured as lag06 and an IQR increase of 7-day moving average concentrations of NO2 resulted in a 24.0% increase of getting PUB (95% CI: 2.6%–50.0%). Significance: Our findings strengthen the hypothesis that short-term air pollution exposure has adverse health effects on digestive system. © 2021 Elsevier Ltd
关键词	Air pollution Case-crossover study Peptic ulcer bleeding Short-term exposure
语种	英语
scopus关键词	Air pollution; Digestive system; Inverse problems; Nitrogen oxides; Patient monitoring; Regression analysis; Risk assessment; Case crossovers; Case-crossover study; Confidence interval; Health concerns; Inter quartile ranges; NO $-2$; Peptic ulcer bleeding; Peptic ulcers; Short-term exposure; Ulcer bleedings; Diseases; carbon monoxide; nitrogen dioxide; ozone; sulfur dioxide; atmospheric pollution; concentration (composition); particulate matter; pollution exposure; public health; regression analysis; risk assessment; adult; aged; air pollutant; air pollution; Article; case control study; China; cohort analysis; female; gastroscopy; human; major clinical study; male; middle aged; particulate matter 10; particulate matter 2.5; peptic ulcer bleeding; PM2.5 exposure; priority journal; China; Zhejiang
来源期刊	ATMOSPHERIC ENVIRONMENT
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/248412
作者单位	Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, 310058, China; Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Department of Epidemiology and Biostatistics, and National Clinical Research Center for Child Health of the Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China; Department of Epidemiology and Biostatistics, and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China
推荐引用方式 GB/T 7714	Wu M.,Tang M.,Yu Z.,et al. Association between short-term exposure to air pollution and peptic ulcer bleeding: A case-crossover study in China[J],2021,256.
APA	Wu M..,Tang M..,Yu Z..,Mao X..,Chen Y..,...&Chen K..(2021).Association between short-term exposure to air pollution and peptic ulcer bleeding: A case-crossover study in China.ATMOSPHERIC ENVIRONMENT,256.
MLA	Wu M.,et al."Association between short-term exposure to air pollution and peptic ulcer bleeding: A case-crossover study in China".ATMOSPHERIC ENVIRONMENT 256(2021).