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DOI	10.1016/j.atmosenv.2021.118570
	Re-assessing the toxicity of particles from biodiesel combustion: A quantitative analysis of in vitro studies
	Southern D.; Hellier P.; Talibi M.; Leonard M.O.; Ladommatos N.
发表日期	2021
ISSN	1352-2310
卷号	261
英文摘要	Biofuels may reduce road transport carbon intensity; however, it is uncertain whether displacing fossil diesel would alter the engine-derived particulate toxicity. The primary objective of this work was to determine whether there is a fuel effect on the comparative in vitro toxicity of biodiesel exhaust particulates relative to those from fossil diesel. A secondary aim was to determine qualitatively whether the observed outcome is related to the organic phase, namely Polycyclic Aromatic Hydrocarbons (PAHs). In vitro and acellular exposure studies were recovered from a literature survey following the PRISMA framework. Biological responses attributable to biodiesel and paired fossil diesel particles, including particle-extracts were selected. To qualify for inclusion, either of the paired responses must differ statistically significantly (p < 0.05) from the control or each other. Paired responses were assigned to one-of-five categories which best represents the pathophysiological role of the biomarker: inflammation, oxidative stress, cytotoxicity, genotoxicity and mutagenicity. Biodiesel reduced particle toxicity in two-thirds of paired responses, however, there were large differences between biodiesels for category-specific biomarkers. Particles derived from Rapeseed oil Methyl Ester (RME) were less inflammatory, whereas Soybean oil Methyl Ester (SME) particles were more inflammatory than fossil diesel on average. Conversely, SME reduced oxidative stress while few trends emerged for mutagenicity and genotoxicity. The largest fuel effect was observed for cytotoxicity: Waste Cooking Oil Methyl Ester (WCOME) increased and Palm oil Methyl Ester (PME) decreased particle cytotoxicity. Particle-phase PAH emissions compiled on a mass-of-soot basis also followed this trend, however, literature focusing on both these aspects is limited; careful consideration of fuel composition and use of normal primary human cell types and omics technologies, could resolve this open question. This assessment systematically compares biological responses from particulate only exposure, with co-exposure necessarily excluded due to an absence of understanding of how gaseous components modify particulate toxicity. © 2021 Elsevier Ltd
关键词	FAME HVO In vitro PAH Particulate Systematic review
语种	英语
scopus关键词	Biomarkers; Cytotoxicity; Diesel engines; Esters; Mineral oils; Oxidative stress; Palm oil; Particles (particulate matter); Particulate emissions; Polycyclic aromatic hydrocarbons; Soybean oil; Waste incineration; Biological response; FAME; Genotoxicities; HVO; In-vitro; Mutagenicity; Particulates; Polycyclic aromatics; Soybean oil methyl ester; Systematic Review; Biodiesel; biodiesel; palm oil; polycyclic aromatic hydrocarbon; rapeseed oil; soybean oil; biofuel; genotoxicity; mutagenicity; oxidative stress; PAH; particulate matter; quantitative analysis; road transport; Article; body weight; combustion; cooking; fossil; human; in vitro study; mutagenicity; oxidative stress; quantitative analysis; soot; Brassica napus; Glycine max
来源期刊	ATMOSPHERIC ENVIRONMENT
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/248336
作者单位	Department of Mechanical Engineering, University College London, Roberts Building, Torrington Place, London, WC1E 7JE, United Kingdom; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, OX11 0RQ, United Kingdom
推荐引用方式 GB/T 7714	Southern D.,Hellier P.,Talibi M.,et al. Re-assessing the toxicity of particles from biodiesel combustion: A quantitative analysis of in vitro studies[J],2021,261.
APA	Southern D.,Hellier P.,Talibi M.,Leonard M.O.,&Ladommatos N..(2021).Re-assessing the toxicity of particles from biodiesel combustion: A quantitative analysis of in vitro studies.ATMOSPHERIC ENVIRONMENT,261.
MLA	Southern D.,et al."Re-assessing the toxicity of particles from biodiesel combustion: A quantitative analysis of in vitro studies".ATMOSPHERIC ENVIRONMENT 261(2021).