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DOI	10.1016/j.atmosenv.2021.118769
	The effect of short-term fine particulate matter exposure on glucose homeostasis: A panel study in healthy adults
	Peng S.; Sun J.; Liu F.; Li Z.; Wu C.; Xiang H.
发表日期	2022
ISSN	1352-2310
卷号	268
英文摘要	As an emerging risk factor, long-term exposure to fine particulate matter (PM2.5) has been linked to glucose homeostasis in numerous epidemiological researches. However, the acute adverse effects of PM2.5 exposure on glucose homeostasis among healthy population are not well described. The study aims to investigate the short-term association between PM2.5 exposure and glucose homeostasis among the healthy populations. We scheduled 8 repeated physical examinations with venous blood collection every 1–2 weeks from 9 September 2019 to 7 January 2020 in a panel of 70 healthy adults (aged 18–26) in Wuhan, China. We measured the individual hourly PM2.5 concentrations, fasting blood glucose (FBG), insulin (FINS) along HOMA-B and HOMA-IR. The linear mixed-effect model was conducted to evaluate the acute effect of PM2.5 on glucose homeostasis. PM2.5 concentrations range varied from 7.38 to 115.38 μg/m3, with an average level of 38.34 μg/m3. Each 10 μg/m3 increment in 3-days PM2.5 moving average was associated with a 4.19% increase in FINS (95% CI: 2.35, 6.05), 5.95% increase in HOMA-B (95% CI: 3.66, 8.26), and 3.77% increase in HOMA-IR (95% CI: 1.41, 4.64), respectively. We found the adverse effect on HOMA-IR was greater in the overweight (%Change = 7.98; 95% CI: 3.54, 12.61) than in the normal-weight (%Change = 3.35; 95% CI: 1.34, 5.38). And the lifestyle factors, such as exercise also showed a modification effect on the short-term association between PM2.5 and glucose homeostasis. Conclusively, exposure to PM2.5 for short-term, even within hours, was positively associated with elevated IR status and impaired glucose homeostasis in the healthy population. The result may suggest a plausible biological pathway underlying PM2.5 and metabolic events. © 2021 Elsevier Ltd
关键词	Glucose homeostasis Insulin resistance Panel study Personal exposure PM2.5
语种	英语
scopus关键词	Blood; Fins (heat exchange); Glucose; Particles (particulate matter); Adverse effect; Fine particulate matter; Glucose homeostasis; Healthy population; Insulin resistance; Panel studies; Personal exposures; PM 2.5; Risk factors; Term associations; Insulin; insulin; adult; blood; glucose; homeostasis; particulate matter; pollution exposure; risk factor; Article; blood sampling; China; concentration (parameter); controlled study; exercise; female; follow up; glucose blood level; glucose homeostasis; HOMA index; human; human experiment; insulin blood level; lifestyle; major clinical study; male; obesity; panel study; particulate matter; physical examination; PM2.5 exposure; venous blood; China; Hubei; Wuhan
来源期刊	ATMOSPHERIC ENVIRONMENT
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/248149
作者单位	Department of Global Health, School of Health Sciences, Wuhan University, 115# Donghu Road, Wuhan, 430071, China; Global Health Institute, School of Health Sciences, Wuhan University, 115# Donghu Road, Wuhan, 430071, China
推荐引用方式 GB/T 7714	Peng S.,Sun J.,Liu F.,et al. The effect of short-term fine particulate matter exposure on glucose homeostasis: A panel study in healthy adults[J],2022,268.
APA	Peng S.,Sun J.,Liu F.,Li Z.,Wu C.,&Xiang H..(2022).The effect of short-term fine particulate matter exposure on glucose homeostasis: A panel study in healthy adults.ATMOSPHERIC ENVIRONMENT,268.
MLA	Peng S.,et al."The effect of short-term fine particulate matter exposure on glucose homeostasis: A panel study in healthy adults".ATMOSPHERIC ENVIRONMENT 268(2022).