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DOI10.1126/science.aat8657
CGAS in action: Expanding roles in immunity and inflammation
Ablasser A.; Chen Z.J.
Date Issued2019
ISSN0036-8075
Volume363Issue:6431
Other AbstractDNA is highly immunogenic. It represents a key pathogen-associated molecular pattern (PAMP) during infection. Host DNA can, however, also act as a danger-associated molecular pattern (DAMP) and elicit strong inflammatory responses. The cGAS-STING pathway has emerged as a major pathway that detects intracellular DNA. Here, we highlight recent advances on how cGAS and STING mediate inflammatory responses and how these are regulated, allowing cells to readily respond to infections and noxious agent while avoiding the inappropriate sensing of self-DNA. A particular focus is placed on the role of cGAS in the context of sterile inflammatory conditions. Manipulating cGAS or STING may open the door for new therapeutic strategies for the treatment of acute and chronic inflammation relevant to many human diseases. 2017 © The Authors, some rights reserved.
enkeywordscyclic guanosine monophosphate adenosine monophosphate synthase; double stranded DNA; interferon regulatory factor 3; interleukin 6; membrane enzyme; mitochondrial DNA; tumor necrosis factor; unclassified drug; DNA; MB21D1 protein, human; membrane protein; nucleotidyltransferase; Tmem173 protein, human; cell; disease; DNA; immune response; immunity; infectious disease; infectivity; antigen presenting cell; Article; binding affinity; carboxy terminal sequence; crystallography; cyclization; cytokine production; dimerization; efferocytosis; enzyme activity; enzyme structure; gene mutation; genetic predisposition; heterozygosity; homologous recombination; human; immune response; immunogenicity; immunostimulation; immunosurveillance; inflammation; innate immunity; molecular dynamics; nonhuman; priority journal; protein binding; protein conformation; protein domain; protein localization; protein protein interaction; signal transduction; cell compartmentalization; enzyme activation; immunity; immunology; inflammation; metabolism; Cell Compartmentation; DNA; Enzyme Activation; Humans; Immunity; Inflammation; Membrane Proteins; Nucleotidyltransferases
Language英语
journalScience
Document Type期刊论文
Identifierhttp://gcip.llas.ac.cn/handle/2XKMVOVA/246231
AffiliationGlobal Health Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, CH-1015, Switzerland; Howard Hughes Medical Institute, Department of Molecular Biology, Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, United States
Recommended Citation
GB/T 7714
Ablasser A.,Chen Z.J.. CGAS in action: Expanding roles in immunity and inflammation[J],2019,363(6431).
APA Ablasser A.,&Chen Z.J..(2019).CGAS in action: Expanding roles in immunity and inflammation.Science,363(6431).
MLA Ablasser A.,et al."CGAS in action: Expanding roles in immunity and inflammation".Science 363.6431(2019).
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