气候变化领域集成服务门户(CCPortal): CGAS in action: Expanding roles in immunity and inflammation

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DOI	10.1126/science.aat8657
	CGAS in action: Expanding roles in immunity and inflammation
	Ablasser A.; Chen Z.J.
发表日期	2019
ISSN	0036-8075
卷号	363 期号:6431
英文摘要	DNA is highly immunogenic. It represents a key pathogen-associated molecular pattern (PAMP) during infection. Host DNA can, however, also act as a danger-associated molecular pattern (DAMP) and elicit strong inflammatory responses. The cGAS-STING pathway has emerged as a major pathway that detects intracellular DNA. Here, we highlight recent advances on how cGAS and STING mediate inflammatory responses and how these are regulated, allowing cells to readily respond to infections and noxious agent while avoiding the inappropriate sensing of self-DNA. A particular focus is placed on the role of cGAS in the context of sterile inflammatory conditions. Manipulating cGAS or STING may open the door for new therapeutic strategies for the treatment of acute and chronic inflammation relevant to many human diseases. 2017 © The Authors, some rights reserved.
英文关键词	cyclic guanosine monophosphate adenosine monophosphate synthase; double stranded DNA; interferon regulatory factor 3; interleukin 6; membrane enzyme; mitochondrial DNA; tumor necrosis factor; unclassified drug; DNA; MB21D1 protein, human; membrane protein; nucleotidyltransferase; Tmem173 protein, human; cell; disease; DNA; immune response; immunity; infectious disease; infectivity; antigen presenting cell; Article; binding affinity; carboxy terminal sequence; crystallography; cyclization; cytokine production; dimerization; efferocytosis; enzyme activity; enzyme structure; gene mutation; genetic predisposition; heterozygosity; homologous recombination; human; immune response; immunogenicity; immunostimulation; immunosurveillance; inflammation; innate immunity; molecular dynamics; nonhuman; priority journal; protein binding; protein conformation; protein domain; protein localization; protein protein interaction; signal transduction; cell compartmentalization; enzyme activation; immunity; immunology; inflammation; metabolism; Cell Compartmentation; DNA; Enzyme Activation; Humans; Immunity; Inflammation; Membrane Proteins; Nucleotidyltransferases
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/246231
作者单位	Global Health Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, CH-1015, Switzerland; Howard Hughes Medical Institute, Department of Molecular Biology, Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, United States
推荐引用方式 GB/T 7714	Ablasser A.,Chen Z.J.. CGAS in action: Expanding roles in immunity and inflammation[J],2019,363(6431).
APA	Ablasser A.,&Chen Z.J..(2019).CGAS in action: Expanding roles in immunity and inflammation.Science,363(6431).
MLA	Ablasser A.,et al."CGAS in action: Expanding roles in immunity and inflammation".Science 363.6431(2019).