气候变化领域集成服务门户(CCPortal): Spatiotemporal transcriptomic divergence across human and macaque brain development

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DOI	10.1126/science.aat8077
	Spatiotemporal transcriptomic divergence across human and macaque brain development
	Zhu Y.; Sousa A.M.M.; Gao T.; Skarica M.; Li M.; Santpere G.; Esteller-Cucala P.; Juan D.; Ferrández-Peral L.; Gulden F.O.; Yang M.; Miller D.J.; Marques-Bonet T.; Kawasawa Y.I.; Zhao H.; Sestan N.
发表日期	2018
ISSN	0036-8075
卷号	362 期号:6420
英文摘要	Human nervous system development is an intricate and protracted process that requires precise spatiotemporal transcriptional regulation.We generated tissue-level and single-cell transcriptomic data from up to 16 brain regions covering prenatal and postnatal rhesus macaque development. Integrative analysis with complementary human data revealed that global intraspecies (ontogenetic) and interspecies (phylogenetic) regional transcriptomic differences exhibit concerted cup-shaped patterns, with a late fetal-to-infancy (perinatal) convergence. Prenatal neocortical transcriptomic patterns revealed transient topographic gradients, whereas postnatal patterns largely reflected functional hierarchy. Genes exhibiting heterotopic and heterochronic divergence included those transiently enriched in the prenatal prefrontal cortex or linked to autism spectrum disorder and schizophrenia. Our findings shed light on transcriptomic programs underlying the evolution of human brain development and the pathogenesis of neuropsychiatric disorders. © 2018 American Association for the Advancement of Science. All rights reserved.
英文关键词	autism; brain; cell component; developmental biology; evolution; nervous system; RNA; spatiotemporal analysis; animal cell; animal tissue; Article; autism; brain development; brain region; comparative study; controlled study; corpus striatum; dorsolateral prefrontal cortex; embryo; embryo development; fetus; gene expression; genetic conservation; genetic variability; hippocampus; human; human cell; intraspecific variation; molecular dynamics; nerve cell differentiation; nonhuman; ontogeny; pathogenesis; phylogeny; postnatal development; prefrontal cortex; prenatal development; priority journal; rhesus monkey; risk factor; RNA sequence; schizophrenia; sequence alignment; single cell analysis; single cell RNA sequence; transcriptomics; upregulation; validation process; animal; brain; embryology; enzymology; gene expression regulation; genetics; growth, development and aging; nervous system development; Macaca mulatta; transcriptome; Animals; Autism Spectrum Disorder; Brain; Gene Expression Regulation, Developmental; Humans; Macaca mulatta; Neurogenesis; Prefrontal Cortex; Schizophrenia; Transcriptome
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/246178
作者单位	Department of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, United States; Department of Biostatistics, Yale School of Public Health, New Haven, CT, United States; Institute of Evolutionary Biology (UPF-CSIC), PRBB, Barcelona, Spain; Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain; Institut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona, Barcelona, Spain; Institute for Personalized Medicine, Penn State University, College of Medicine, Hershey, PA, United States; Departments of Genetics,Psychiatry, and Comparative Medicine, Neurodegeneration and Repair and Yale Child Study Center, Yale School of Medicine, New Haven, CT, United States
推荐引用方式 GB/T 7714	Zhu Y.,Sousa A.M.M.,Gao T.,et al. Spatiotemporal transcriptomic divergence across human and macaque brain development[J],2018,362(6420).
APA	Zhu Y..,Sousa A.M.M..,Gao T..,Skarica M..,Li M..,...&Sestan N..(2018).Spatiotemporal transcriptomic divergence across human and macaque brain development.Science,362(6420).
MLA	Zhu Y.,et al."Spatiotemporal transcriptomic divergence across human and macaque brain development".Science 362.6420(2018).