气候变化领域集成服务门户(CCPortal): Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells

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DOI	10.1126/science.aal3485
	Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells
	Zhao C.; Cai S.; Shin K.; Lim A.; Kalisky T.; Lu W.-J.; Clarke M.F.; Beachy P.A.
发表日期	2017
ISSN	0036-8075
卷号	356 期号:6335
英文摘要	The stem cell niche is a complex local signaling microenvironment that sustains stem cell activity during organ maintenance and regeneration. The mammary gland niche must support its associated stem cells while also responding to systemic hormonal regulation that triggers pubertal changes. We find that Gli2, the major Hedgehog pathway transcriptional effector, acts within mouse mammary stromal cells to direct a hormoneresponsive niche signaling program by activating expression of factors that regulate epithelial stem cells as well as receptors for the mammatrophic hormones estrogen and growth hormone.Whereas prior studies implicate stem cell defects in human disease, this work shows that niche dysfunction may also cause disease, with possible relevance for human disorders and in particular the breast growth pathogenesis associated with combined pituitary hormone deficiency. Copyright 2016 by the American Association for the Advancement of Science, all rights reserved.
英文关键词	CD147 antigen; estrogen; fibroblast growth factor; growth hormone; polymer; recombinase; scatter factor; somatomedin; somatomedin C; transcription factor Gli2; Wnt protein; Wnt2 protein; estrogen; Gli2 protein, mouse; growth hormone; IGF2 protein, mouse; prolactin; somatomedin B; sonic hedgehog protein; Wnt protein; WNT2A protein, mouse; zinc finger protein GLI2; anatomy; cells and cell components; disease incidence; hormone; protein; rodent; adult; allele; animal cell; animal experiment; animal tissue; Article; breast development; breast epithelium cell; cell activity; cell regeneration; cell renewal; controlled study; female; fluorescence activated cell sorting; hormonal regulation; hormone response; mammary gland; microenvironment; morphogenesis; mouse; nonhuman; phenotype; priority journal; protein expression; protein function; signal transduction; single cell analysis; stem cell; stem cell niche; stroma; stroma cell; animal; blood; cytology; deficiency; epithelium cell; gene expression; genetics; growth, development and aging; metabolism; physiology; sexual maturation; signal transduction; stem cell niche; udder; Erinaceidae; Animals; Epithelial Cells; Estrogens; Female; Gene Expression; Growth Hormone; Hedgehog Proteins; Insulin-Like Growth Factor II; Mammary Glands, Animal; Mice; Prolactin; Sexual Maturation; Signal Transduction; Stem Cell Niche; Stromal Cells; Wnt Proteins; Zinc Finger Protein Gli2
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/246165
作者单位	Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, United States; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyumgbuk, 37673, South Korea; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, United States; Faculty of Engineering and Institute for Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, 52900, Israel; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, United States; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States
推荐引用方式 GB/T 7714	Zhao C.,Cai S.,Shin K.,et al. Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells[J],2017,356(6335).
APA	Zhao C..,Cai S..,Shin K..,Lim A..,Kalisky T..,...&Beachy P.A..(2017).Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells.Science,356(6335).
MLA	Zhao C.,et al."Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells".Science 356.6335(2017).