气候变化领域集成服务门户(CCPortal): Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition

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DOI	10.1126/science.aam5339
	Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition
	Zenk F.; Loeser E.; Schiavo R.; Kilpert F.; Bogdanovic O.; Iovino N.
发表日期	2017
ISSN	0036-8075
起始页码	212
结束页码	216
卷号	357 期号:6347
英文摘要	Gametes carry parental genetic material to the next generation. Stress-induced epigenetic changes in the germ line can be inherited and can have a profound impact on offspring development. However, the molecular mechanisms and consequences of transgenerational epigenetic inheritance are poorly understood. We found that Drosophila oocytes transmit the repressive histone mark H3K27me3 to their offspring. Maternal contribution of the histone methyltransferase Enhancer of zeste, the enzymatic component of Polycomb repressive complex 2, is required for active propagation of H3K27me3 during early embryogenesis. H3K27me3 in the early embryo prevents aberrant accumulation of the active histone mark H3K27ac at regulatory regions and precocious activation of lineage-specific genes at zygotic genome activation. Disruption of the germ line–inherited Polycomb epigenetic memory causes embryonic lethality that cannot be rescued by late zygotic reestablishment of H3K27me3. Thus, maternally inherited H3K27me3, propagated in the early embryo, regulates the activation of enhancers and lineage-specific genes during development. © 2017 The Authors, some rights reserved.
英文关键词	histone H3; histone methyltransferase; DNA binding protein; Drosophila protein; histone; histone lysine methyltransferase; histone methyltransferase; polycomb repressive complex 2; z protein, Drosophila; activation energy; embryo; enzyme; fly; genetic analysis; genetic marker; memory; molecular analysis; protein; allele; Article; cell differentiation; chromatin immunoprecipitation; controlled study; Drosophila; ectopic expression; embryo development; enhancer region; female; germ line; histone modification; Hox gene; male; nonhuman; nuclear division; oocyte; priority journal; promoter region; sperm; upregulation; animal; Drosophila melanogaster; embryo death; embryo development; embryology; gene expression regulation; genetic epigenesis; genetics; maternal inheritance; metabolism; zygote; Animals; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Embryo Loss; Embryonic Development; Enhancer Elements, Genetic; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Histone-Lysine N-Methyltransferase; Histones; Maternal Inheritance; Oocytes; Polycomb Repressive Complex 2; Zygote
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/246142
作者单位	Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, D-79108, Germany; Faculty of Biology, University of Freiburg, Freiburg, D-79104, Germany; Bioinformatics Facility, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, D-79108, Germany; Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, NSW, Australia; St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia; ARC Centre of Excellence in Plant Energy Biology, University of Western Australia, Perth, WA 6009, Australia
推荐引用方式 GB/T 7714	Zenk F.,Loeser E.,Schiavo R.,等. Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition[J],2017,357(6347).
APA	Zenk F.,Loeser E.,Schiavo R.,Kilpert F.,Bogdanovic O.,&Iovino N..(2017).Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition.Science,357(6347).
MLA	Zenk F.,et al."Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition".Science 357.6347(2017).