气候变化领域集成服务门户(CCPortal): Regional myocardial substrate uptake in hypertensive rats: A quantitative autoradiographic measurement

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DOI	10.1126/science.3975623
	Regional myocardial substrate uptake in hypertensive rats: A quantitative autoradiographic measurement
	Yonekura Y.; Brill A.B.; Som P.; Yamamoto K.; Srivastava S.C.; Iwai J.; Elmaleh D.R.; Livni E.; Strauss H.W.; Goodman M.M.; Knapp Jr. F.F.
发表日期	1985
ISSN	0036-8075
起始页码	1494
结束页码	1496
卷号	227 期号:4693
英文摘要	Severe hypertension causes global and regional changes in myocardial perfusion and substrate utilization. Regional perfusion and fatty acid utilization were evaluated by dual-tracer autoradiography in normotensive and hypertensive rats of the Dahl strain. The regional distributions of perfusion and fatty acid utilization were homogeneous in normotensive rats. Severe hypertension was associated with a homogeneous pattern of regional perfusion, but fatty acid utilization was focally decreased in the free wall of the left ventricle. The decrease in fatty acid uptake was associated with a concomitant increase in glucose utilization. These findings suggest that severe hypertension is associated with uniform myocardial perfusion and focal alterations in the substrates used for the performance of myocardial work.
英文关键词	carbon 14; fatty acid; fluorine 18; glucose; radioisotope; thallium 201; animal experiment; autoradiography; cardiovascular system; diagnosis; heart; heart muscle metabolism; hypertension; nonhuman; priority journal; rat; Animals; Autoradiography; Deoxyglucose; Endocardium; Fatty Acids; Fluorodeoxyglucose F18; Glucose; Heart Septum; Hypertension; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Tissue Distribution; Animalia
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/246107
作者单位	Brookhaven National Laboratory, Medical Department, Upton, NY 11973; Department of Radiology, Massachusetts General Hospital, Boston, MA 02114; Oak Ridge National Laboratory, Oak Ridge, TN 37830
推荐引用方式 GB/T 7714	Yonekura Y.,Brill A.B.,Som P.,et al. Regional myocardial substrate uptake in hypertensive rats: A quantitative autoradiographic measurement[J],1985,227(4693).
APA	Yonekura Y..,Brill A.B..,Som P..,Yamamoto K..,Srivastava S.C..,...&Knapp Jr. F.F..(1985).Regional myocardial substrate uptake in hypertensive rats: A quantitative autoradiographic measurement.Science,227(4693).
MLA	Yonekura Y.,et al."Regional myocardial substrate uptake in hypertensive rats: A quantitative autoradiographic measurement".Science 227.4693(1985).